Table 1.
Comparison of means of different variables between subtypes in the discovery sample, after correction for age (except in the case of age), sex (except in the case of sex), education (except in the case of education), cohort, clinical diagnosis (i.e. CN, MCI, AD), and SuStaIn stage (except comparisons with S0). Standard deviations are given in parentheses where relevant. All p-values were corrected for multiple comparisons.
| S0: No Tau | S1: Limbic | S2: MTL-Sparing | S3: Posterior | S4: L Temporal | |
|---|---|---|---|---|---|
|
|
|||||
| n | 687 | 137 | 73 | 131 | 80 |
| Age | 71.52 (8.1) | 75.28 (7.7)# | 71.34 (8.3)* | 75.06 (7.3)# | 73.41 (6.9) |
| Prop. Female | 0.49 | 0.70# | 0.60‡ | 0.64# | 0.56 |
| Education | 15.17 (2.9) | 14.42 (3.9) | 14.29 (4.0) | 14.6 (3.0) | 14.82 (2.9) |
| Prop. APOE4 Carrier | 0.26 | 0.75#* | 0.47* | 0.63# | 0.59# |
| Cortical Tau SUVR | 1.04 (0.1) | 1.41 (0.1)#* | 1.44 (0.1)# | 1.44 (0.1)# | 1.47 (0.1)#* |
| Laterality | 0.0 (0.2) | −0.28 (1.3)*#R | −0.13 (1.6)‡*R | 0.04 (1.5) | 1.95 (1.2)#*L |
| MMSE | 28.9 (1.5) | 24.33 (3.0)# | 24.32 (4.2)# | 24.19 (3.0)# | 23.33 (5.0)# |
| Global Cognition | 0.36 (0.5) | −0.03 (0.8)* | −0.29 (0.8)# | −0.23 (0.8)# | −0.39 (0.9)#† |
| Abs. Memory | 0.48 (0.7) | −0.62 (0.7)#† | −0.36 (0.7)# | −0.55 (0.7)# | −0.3 (0.8)#† |
| Abs. Language | 0.22 (0.7) | −0.11 (0.8) | 0.01 (0.9) | −0.18 (0.8) | −0.64 (1.1)#* |
| Abs. Executive | 0.19 (0.6) | 0.02 (0.9) | −0.33 (0.9)# | 0.03 (0.8) | −0.17 (1.0)‡ |
| Abs. Visuospatial | 0.19 (0.6) | 0.08 (1.0) | −0.25 (1.2)# | −0.23 (1.2)# | −0.09 (1.0) |
| Rel. Memory | 0.26 (0.8) | −0.61 (1.0)#* | −0.14 (1.0) | −0.37 (1.0)# | −0.06 (1.1)* |
| Rel. Language | −0.02 (0.8) | 0.05 (1.0) | 0.31 (1.2)# | 0.06 (1.0) | −0.51 (1.3)#* |
| Rel. Executive | −0.14 (0.8) | 0.25 (1.0)‡ | −0.22 (1.0)‡* | 0.38 (1.1)# | 0.22 (1.2) |
| Rel. Visuospatial | −0.1 (0.7) | 0.31 (1.1)‡ | 0.03 (1.3) | 0.0 (1.3) | 0.27 (1.3) |
MMSE = Mini-Mental State Examination; Abs. = Absolute; Rel. = Relative; Prop. = Proportion
= Adj. p$<$0.05 (vs all other subtypes, not including S0)
= Adj. p$<$0.1 (vs all other subtypes, not including S0)
= Adj. p$<$0.05 (vs S0)
= Adj. p$<$0.1 (vs S0).
= Significant right-sided laterality in this subtype compared to others
= Significant left-sides laterality in this subtype compared to other subtypes.