Table 2.
Ratio between the mean AAD/6W in each subgroup category and the within-arm mean AAD/6W (FAS)
| Parameter | DA (comparative) | Roxadustat (comparative) | Difference | p value |
|---|---|---|---|---|
| ERI | ||||
| <1.9 | 0.739 | 0.899 | 0.160 | 0.203 |
| ≥1.9–<3.5 | 0.793 | 0.917 | 0.124 | 0.413 |
| ≥3.5–<6.8 | 0.967 | 0.922 | −0.045 | 0.753 |
| ≥6.8 | 1.541 | 1.219 | −0.322 | 0.085 |
| Hs-CRP by nmol/L cutoff | ||||
| <28.57 | 0.946 | 0.986 | 0.040 | 0.628 |
| ≥28.57 | 1.230 | 1.066 | −0.164 | 0.493 |
| DM | ||||
| With | 0.838 | 1.038 | 0.200 | 0.020 |
| Without | 1.175 | 0.959 | −0.216 | 0.120 |
| eGFR by mL/min/1.73m2 cutoff | ||||
| <15 | 1.239 | 1.048 | −0.191 | 0.192 |
| ≥15 | 0.785 | 0.963 | 0.178 | 0.025 |
| Primary disease of CKD | ||||
| CGN | 1.058 | 0.955 | −0.103 | 0.640 |
| DN | 0.789 | 1.049 | 0.260 | 0.007 |
| NS | 1.219 | 0.989 | −0.229 | 0.179 |
| Other | 1.000 | 0.933 | −0.067 | 0.786 |
| Concomitant ACEi/ARB use | ||||
| Yes | 0.984 | 0.995 | 0.011 | 0.896 |
| No | 1.080 | 1.023 | −0.057 | 0.796 |
| GNRI category | ||||
| <95.1 | 1.217 | 0.986 | −0.231 | 0.274 |
| ≥95.1–<98.3 | 1.100 | 0.898 | −0.202 | 0.263 |
| ≥98.3–<101.3 | 0.898 | 1.044 | 0.146 | 0.540 |
| ≥101.3–<104.2 | 0.746 | 1.014 | 0.269 | 0.034 |
| ≥104.2 | 1.053 | 1.039 | −0.014 | 0.935 |
| PNI category | ||||
| <43.6 | 1.199 | 1.054 | −0.145 | 0.415 |
| ≥43.6–<46.8 | 1.071 | 0.941 | −0.131 | 0.486 |
| ≥46.8–<49.7 | 0.946 | 0.974 | 0.028 | 0.858 |
| ≥49.7 | 0.767 | 1.018 | 0.250 | 0.048 |
AAD/6W, average allocated dose of roxadustat or DA per administration in the last 6 weeks; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ERI, erythropoiesis-stimulating agent resistance index; FAS, full analysis set; GNRI, geriatric nutritional risk index; PNI, prognostic nutritional index; TSAT, transferrin saturation; DA, darbepoetin alfa; hs-CRP, high-sensitivity C-reactive protein; DM, diabetes mellitus; CGN, chronic glomerular nephritis; DN, diabetic nephropathy; NS, nephrosclerosis.