Table 6.
The incidence of NAFLD overall and by subgroup
| Studies, n | Participants, n | Incidence (per 1,000 person-years, 95% CI) | I2, % | p value | |
|---|---|---|---|---|---|
| Overall incidence | 18 | 1,026,346 | 42.8 (38.6–47.1) | 99.7 | |
| By sex | |||||
| Male | 14 | 306,501 | 50.6 (40.9−61.3) | 99.9 | <0.0001 |
| Female | 12 | 356,978 | 19.8 (16.4–23.6) | 99.7 | |
| Metabolic syndrome | |||||
| Yes | 5 | 1,059 | 77.1 (63.9−91.4) | 51.2 | <0.0001 |
| No | 5 | 7,746 | 43.5 (34.5–53.5) | 93.3 | |
| Type 2 diabetes mellitus | |||||
| Yes | 4 | 1,838 | 70.9 (65.3−76.7) | 0.0 | <0.0001 |
| No | 4 | 145,534 | 45.1 (43.2–47.0) | 60.4 | |
| Smoking | |||||
| Yes | 8 | 88,951 | 57.5 (52.1−63.2) | 97.9 | <0.0001 |
| No | 8 | 258,754 | 32.5 (29.2–36.1) | 99.0 | |
| Hypertension | |||||
| Yes | 2 | 12,590 | 71.0 (68.9−73.2) | 0.0 | <0.0001 |
| No | 2 | 132,765 | 42.7 (40.3–45.2) | 85.1 | |
Italic values emphasize those subgroups with certain risk factors of NAFLD. References for included studies are provided in online supplementary Table 2. NAFLD, nonalcoholic fatty liver disease.