TABLE 1.
Metabolic pathways that significantly affected by the NTRK1Arg748Trp variant (in reverse order of comprehensive significance).
| KEGG (kyoto encyclopedia of genes and genomes) | Total | Hits | Raw p | Impact |
|---|---|---|---|---|
| Purine metabolism | 65 | 4 | 0.0082243 | 0.06541 |
| Glycerophospholipid metabolism | 36 | 3 | 0.010002 | 0.21631 |
| Linoleic acid metabolism | 5 | 1 | 0.062952 | 0 |
| Taurine and hypotaurine metabolism | 8 | 1 | 0.098896 | 0 |
| Sulfur metabolism | 8 | 1 | 0.098896 | 0 |
| Primary bile acid biosynthesis | 46 | 2 | 0.11678 | 0.01446 |
| Alpha-linolenic acid metabolism | 13 | 1 | 0.15591 | 0 |
| Glycosylphosphatidylinositol (GPI)–anchor biosynthesis | 14 | 1 | 0.16689 | 0.00399 |
| Nicotinate and nicotinamide metabolism | 15 | 1 | 0.17774 | 0.23465 |
| Sphingolipid metabolism | 21 | 1 | 0.24006 | 0.03854 |
| Glutathione metabolism | 28 | 1 | 0.3071 | 0.02698 |
| Porphyrin and chlorophyll metabolism | 30 | 1 | 0.3252 | 0.02955 |
| Glycine, serine and threonine metabolism | 33 | 1 | 0.3515 | 0 |
| Arachidonic acid metabolism | 36 | 1 | 0.37683 | 0 |
| Arginine and proline metabolism | 38 | 1 | 0.39319 | 0.01212 |
| Drug metabolism-cytochrome P450 | 55 | 1 | 0.5167 | 0 |
*Total, the total number of compounds in the pathway; Hits, the actually matched number from the user uploaded data; Raw p, the original p value calculated from the enrichment analysis; Impact, the pathway impact value calculated from pathway topology analysis.