Table II.
Correlation between clinicopathological parameters and immunoreactivity for HSP90, p53, E-cadherin and HPV in oral lichen planus.
| Parameter | HSP90, n (%) | p53, n (%) | E-cadherin, n (%) | HPV16/18, n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | Negative | Positive | p-value | |
| Age | ||||||||||||
| < 60 years | 9 (52.9) |
8 (47.1) |
0.771a | 13 (76.5) |
4 (23.5) |
0.362a | 6 (35.3) |
11 (64.7) |
0.822a | 17 (100.0) | 0 (0.0) |
0.171a |
| ≥ 60 years | 19 (48.7) |
20 (51.3) |
25 (64.1) |
14 (35.9) |
15 (38.5) |
24 (61.5) |
35 (89.7) |
4 (10.3) |
||||
| Gender | ||||||||||||
| Female | 15 (42.9) |
20 (57.1) |
0.084b | 21 (60.0) |
14 (40.0) |
0.104a | 16 (45.7) |
19 (54.2) |
0.036 b | 31 (88.6) |
4 (11.4) |
0.108a |
| Male | 13 (61.9) |
8 (38.9) |
17 (81.0) |
4 (19.0) |
5 (23.8) |
16 (76.2) |
21 (100.0) | 0 (0.0) |
||||
| Duration | ||||||||||||
| ≤ 37 months | 23 (62.2) |
14 (37.8) |
0.011 a | 26 (70.3) |
11 (29.7) |
0.589a | 18 (48.6) |
19 (51.4) |
0.016 a | 36 (97.3) |
1 (2.7) |
0.072a |
| > 37 months | 5 (26.3) |
14 (73.7) |
12 (63.2) |
7 (36.8) |
3 (15.8) |
16 (84.2) |
16 (84.2) |
3 (15.8) |
||||
| Tumour site | ||||||||||||
| Buccal mucosa |
12 (44.4) |
15 (55.6) |
0.503a | 22 (81.5) |
5 (18.5) |
0.025 c | 13 (48.1) |
14 (51.9) |
0.282a | 26 (96.3) |
1 (3.7) |
0.432a |
| General involvement |
13 (52.0) |
12 (48.0) |
13 (52.0) |
12 (48.0) |
7 (28.0) |
18 (72.0) |
22 (88.0) |
3 (12.0) |
||||
| Other | 3 (75.0) |
1 (25.0) |
3 (75.0) |
1 (25.0) |
1 (25.0) |
3 (75.0) |
4 (100.0) |
0 (0.0) |
||||
| Clinical type | ||||||||||||
| White striae | 21 (48.8) |
22 (51.2) |
0.752a | 27 (62.8) |
16 (37.2) |
0.140a | 18 (41.9) |
25 (58.1) |
0.220a | 40 (93.0) |
3 (7.0) |
0.930a |
| Erosive | 7 (53.8) |
6 (46.2) |
11 (84.6) |
2 (15.4) |
3 (23.1) |
10 (76.9) |
12 (92.3) |
1 (7.7) |
||||
| Total OLP | 28 (50.0) | 28 (50.0) | 38 (67.9) | 18 (32.1) | 21 (37.5) | 35 (62.5) | 52 (92.9) | 4 (7.1) | ||||
a Chi-square test;
b Mann-Whitney U-test;
c Kruskal-Wallis test.
Bold values indicate statistical significance (p < 0.05).