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. 2021 Dec 20;18(1):6. doi: 10.1007/s11306-021-01859-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Level of selected compounds for significant change in level between first and last patient sample. Ureidopropionate (A), uracil (B), arginine (C) and tryptophan (D) levels showed significantly different evolution measured by logistic regression OR and 95%CI. Y axes reflect the difference in ion counts or peak areas difference between the first sample and last sample per patient. Boxplot markings follow the same standard as Fig. 4