Table 3.
Prognostic Factors Associated with Mortality Among Patients with Advanced HCC in Palliative Treatment: A Multivariate Cox Regression Univariate and Multivariate Analysis
| Parameters | Univariate Analysis | Multivariate Analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted HR | Adjusted HR | ||||||||
| HR | 95%CI | p | HR | 95%CI | p | HR | 95%CI | p | |
| Age | 0.99 | 0.98–1.02 | 0.9 | 0.99 | 0.95–1.04 | 0.8 | |||
| Gender (M vs F) | 1.34 | 0.73–2.46 | 0.3 | 1.7 | 0.5–6.3 | 0.4 | |||
| Hemoglobin level | 1.17 | 1.003–1.37 | 0.04 | 1.3 | 0.97–1.8 | 0.1 | 1.36 | 1.1–1.7 | 0.02 |
| ALT | 1.001 | 1.00–1.002 | 0.03 | 1.000 | 0.999–1.002 | 0.6 | |||
| CTP | 1.28 | 1.06–1.55 | 0.01 | 0.6 | 0.3–1.2 | 0.1 | |||
| BCLC | 0.04 | 0.01 | |||||||
| Stage B | Ref | – | Ref | – | – | ||||
| Stage C | 1.3 | 0.62–2.7 | 0.48 | 0.1–2.2 | |||||
| Stage D | 2.5 | 1.2–5.1 | 1.34 | 0.2–8.5 | |||||
| MELD | 1.1 | 1.04–1.14 | 0.001 | 1.09 | 1.01–1.17 | 0.02 | 1.10 | 1.03–1.17 | 0.01 |
| NLR | 1.1 | 1.01–1.2 | 0.04 | 1.1 | 0.98–1.29 | 0.1 | 1.12 | 1.01–1.23 | 0.03 |
| PLR | 1.003 | 1.001–1.009 | 0.02 | 1.003 | 0.99–1.009 | 0.4 | – | – | – |
Notes: The CTP, MELD scores, NLR and PLR were used as continuous variables in the model. C-index (SE) of the final model=0.71 (0.069); Wald test=19.48, df=3, p=0.0001. Variables with significant collinearity were not included in the models.
Abbreviations: HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; CTP, Child–Turcotte–Pugh; MELD, model for end-stage liver disease; BCLC, Barcelona clinic liver cancer; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.