Table 1.
Evaluation of gene regulatory networks in response to the GSE25612 lung gene expression data
| KEGG ID | Descriptor | Node | Edge | Light | Dark | ||
|---|---|---|---|---|---|---|---|
| P ‐value | FDR | P ‐value | FDR | ||||
| rno05152 | tuberculosis | 42 | 163 | 7.59 × 10–8 | 3.11 × 10–6 | 1.04 × 10–3 | 9.40 × 10–3 |
| rno04710 | circadian rhythm – mammal | 13 | 58 | 1.00 × 10–5 | 1.37 × 10–4 | 5.34 × 10–5 | 1.09 × 10–3 |
| rno05200 | pathways in cancer | 82 | 170 | 6.99 × 10–5 | 4.29 × 10–4 | 9.84 × 10–3 | 0.0576 |
| rno04630 | Jak‐STAT signalling pathway | 25 | 90 | 7.33 × 10–5 | 4.29 × 10–4 | 0.9450 | 0.9587 |
| rno04310 | wnt signalling pathway | 13 | 40 | 2.52 × 10–3 | 0.0115 | 6.61 × 10–3 | 0.0451 |
| rno05216 | thyroid cancer | 7 | 10 | 0.0210 | 0.0860 | 0.1150 | 0.2946 |
| rno05213 | endometrial cancer | 7 | 10 | 0.0252 | 0.0938 | 0.1101 | 0.2946 |
| rno05211 | renal cell carcinoma | 13 | 22 | 0.0463 | 0.1582 | 0.0981 | 0.2871 |
| rno05212 | pancreatic cancer | 9 | 20 | 0.0527 | 0.1661 | 0.1942 | 0.3520 |
| rno05143 | African trypanosomiasis | 6 | 5 | 0.0874 | 0.2561 | 0.1875 | 0.3520 |
| rno05215 | prostate cancer | 9 | 7 | 0.1147 | 0.2985 | 0.2408 | 0.3901 |
| rno04350 | TGF‐beta signalling pathway | 20 | 26 | 0.1219 | 0.2985 | 0.1865 | 0.3520 |
| rno04510 | focal adhesion | 5 | 6 | 0.1238 | 0.2985 | 0.0319 | 0.1191 |
| rno04978 | mineral absorption | 6 | 5 | 0.1547 | 0.3375 | 0.2185 | 0.3732 |
| rno05217 | basal cell carcinoma | 19 | 38 | 0.1564 | 0.3375 | 0.7837 | 0.8902 |
| rno04916 | melanogenesis | 15 | 14 | 0.2001 | 0.3935 | 0.3057 | 0.4643 |
| rno04976 | bile secretion | 13 | 12 | 0.2102 | 0.3935 | 0.4905 | 0.6487 |
| rno05134 | legionellosis | 14 | 12 | 0.2244 | 0.3935 | 0.4397 | 0.6217 |
| rno05218 | melanoma | 6 | 5 | 0.2257 | 0.3935 | 0.9124 | 0.9587 |
| rno04210 | apoptosis | 8 | 12 | 0.2436 | 0.3935 | 0.1367 | 0.3297 |
| rno04150 | mTOR signalling pathway | 6 | 5 | 0.2560 | 0.3935 | 0.7494 | 0.8778 |
| rno04961 | endocrine and other factor‐regulated calcium reabsorption | 6 | 7 | 0.2614 | 0.3935 | 0.8818 | 0.9514 |
| rno04960 | aldosterone‐regulated sodium reabsorption | 16 | 15 | 0.2645 | 0.3935 | 0.1703 | 0.3520 |
| rno04340 | hedgehog signalling pathway | 22 | 40 | 0.2773 | 0.3935 | 0.7093 | 0.8778 |
| rno04962 | vasopressin‐regulated water reabsorption | 7 | 6 | 0.2783 | 0.3935 | 0.7470 | 0.8778 |
| rno05031 | amphetamine addiction | 13 | 28 | 0.2883 | 0.3941 | 0.1974 | 0.3520 |
| rno05222 | small cell lung cancer | 25 | 38 | 0.2997 | 0.3964 | 0.0270 | 0.1107 |
| rno04910 | insulin signalling pathway | 6 | 5 | 0.3211 | 0.4114 | 0.0200 | 0.0913 |
| rno04950 | maturity onset diabetes of the young | 20 | 28 | 0.5106 | 0.6214 | 0.9587 | 0.9587 |
| rno04115 | p53 signalling pathway | 32 | 31 | 0.5153 | 0.6214 | 0.4777 | 0.6487 |
| rno04620 | toll‐like receptor signalling pathway | 12 | 11 | 0.6041 | 0.7077 | 0.6175 | 0.7912 |
| rno05220 | chronic myeloid leukaemia | 5 | 3 | 0.7017 | 0.7992 | 0.3982 | 0.5830 |
| rno04110 | cell cycle | 20 | 26 | 0.7254 | 0.8038 | 0.0495 | 0.1690 |
| rno04920 | adipocytokine signalling pathway | 9 | 10 | 0.8524 | 0.8997 | 0.8034 | 0.8902 |
| rno05030 | cocaine addiction | 16 | 22 | 0.8558 | 0.8997 | 0.1461 | 0.3328 |
| rno03320 | PPAR signalling pathway | 64 | 258 | 0.9756 | 0.9956 | 5.26 × 10–13 | 2.16 × 10–11 |
| rno05221 | acute myeloid leukaemia | 12 | 10 | 0.9956 | 0.9956 | 0.2473 | 0.3901 |