Table 1.
Significant motifs in the human transcriptional regulatory network
| Motif ID | Motif type | Occur (Real) | Occur (Rand) | Z ‐score (Real) | p ‐value | UV | [ ] |
|---|---|---|---|---|---|---|---|
| 46 | three‐node | 470 | 327.8 + −28.0 | 5.08 | 0.000 | 9 | 0.483 |
| 222 | four‐node | 4913 | 2864.9 + −451.9 | 4.53 | 0.000 | 8 | 0.029 |
| 908 | four‐node | 950 | 751.4 + −93.6 | 2.12 | 0.000 | 7 | 0.006 |
| 972 | four‐node | 703 | 363.1 + −74.4 | 4.57 | 0.000 | 4 | 0.004 |
| 2206 | four‐node | 486 | 306.2 + −44.2 | 4.07 | 0.000 | 5 | 0.003 |
| 2462 | four‐node | 264 | 162.0 + −42.6 | 2.40 | 0.000 | 4 | 0.002 |
We identified six types of statistically significant three‐ and four‐node motifs. ‘Occur (Real)’ indicates the number of times the motif occurred in the real network, ‘Occur (Rand)’ is the mean number of occurrences in random networks (shown with standard deviation), ‘Z ‐score (Real)’ is the Z ‐score for motifs in the real network, ‘p ‐value’ is the significance of the occurrence of motifs in the real network as reported by mFinder (p < 0.010), ‘UV’ is the unique value, which is the number of times a motif appears in the real network with a completely different (disjoint) set of genes, ‘[ ]’ is the concentration (×10−3 ), which is the ratio of the number of occurrences of a motif against other motifs of the same size in the real network.