Table 2.
Topological features of the generic, core and ovarian cancer specific transcriptional regulatory networks
| Network type | No. of nodes | No. of edges | Hubs | Network heterogeneity | Characteristic path length | Avg. degree |
|---|---|---|---|---|---|---|
| Generic network | ||||||
| TF–miRNA interaction | 409 | 670 | MYC, EGR1, E2F1, TP53, miR‐21 | 1.26 | 5.07 | 3.27 |
| TF–gene interaction | 3801 | 6071 | HIF1A, TP53, FOS, STAT1, RUNX1, EGR1 | 5.78 | 3.87 | 3.19 |
| miRNA–gene interaction | 1469 | 1881 | miR‐124‐3p, miR‐16‐5p, miR‐93‐5p, miR‐1, miR‐19b‐3p, miR‐130b‐3p | 2.73 | 5.35 | 2.56 |
| Whole generic network | 5156 | 8622 | HIF1A, TP53, EGR1, FOS, RUNX1 | 4.50 | 4.55 | 2.84 |
| Core network | ||||||
| TF–miRNA interaction | 215 | 326 | MYC, EGR1, E2F1, NFKB1, TP53 | 1.74 | 4.33 | 2.57 |
| TF–gene interaction | 197 | 239 | HIF1A, TP53, RUNX1, EGR1, FOS, SP1 | 2.12 | 4.51 | 2.29 |
| miRNA–gene interaction | 282 | 272 | miR‐93‐5p, miR‐16‐5p, miR‐124‐3p, miR‐19b‐3p, miR‐29c‐3p, VEGFA | 1.01 | 6.64 | 1.93 |
| Whole core network | 461 | 757 | HIF1A, EGR1, TP53, E2F1, MYC | 1.66 | 4.27 | 3.28 |
| Ovarian cancer specific subnetwork | ||||||
| TF–miRNA interaction | 112 | 225 | MYC, NFKB1, TGFB1, miR‐21, miR‐155, miR‐200c, miR‐200b | 1.07 | 4.08 | 3.16 |
| TF–gene interaction | 1121 | 1291 | HIF1A, TP53, EGR1, ETS1, GATA3, SP1 | 6.9 | 3.74 | 2.3 |
| miRNA–gene interaction | 69 | 65 | miR‐30a‐5p, miR 429, miR‐206, miR142‐3p, miR‐30e‐ 5p, LIMCH1 | 2.78 | 2.06 | 1.88 |
| Whole network | 1277 | 1611 | HIF1A, TP53, EGR1, ETS1, GATA3 | 6.24 | 3.78 | 2.44 |