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. 2021 Dec 6;12:791648. doi: 10.3389/fphar.2021.791648

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Copyright © 2021 Murao, Tan, Jha, Wang and Aziz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An exosome inhibitor GW4869 attenuates eCIRP release. (A) RAW 264.7 cells were treated with PBS, LPS or LPS + GW4869. After 20 h eCIRP levels of the supernatants were assessed by Western blotting. Data are expressed as means ± SE (n = 4 samples/group). The groups were compared by two-way ANOVA and SNK method (^* p < 0.05 vs PBS; ^# p < 0.05 vs LPS). (B) Mice were injected with PBS, LPS or LPS + GW4869. After 4 h the serum was harvested and eCIRP levels were assessed by ELISA. Data are expressed as means ± SE (n = 5 samples/group). The groups were compared by two-way ANOVA and SNK method (^* p < 0.05 vs PBS; ^# p < 0.05 vs LPS). (C) Mice were subjected to sham surgery, CLP or CLP with GW4869 instillation. After 20 h the serum was harvested and eCIRP levels were assessed by ELISA. Data are expressed as means ± SE (n = 6 samples/group). The groups were compared by two-way ANOVA and SNK method (^* p < 0.05 vs Sham; ^# p < 0.05 vs CLP).