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. 2021 Dec 20;16(12):e0247261. doi: 10.1371/journal.pone.0247261

Fig 11. Confirmation of mRNA expression changes in Poldip2 knockout mice.

Fig 11

RNA purified from the endothelial and medial layers of thoracic aorta was analyzed by RT-qPCR. Bar graphs represent mRNA expression in Poldip2-/- mice, relative to Poldip2+/+ littermate controls. Mitochondrially-encoded genes were downregulated in the endothelial fraction (top). In the medial fraction (bottom), genes coding for extracellular matrix, integrins and cytoskeletal proteins were upregulated. Bars represent m ± SEM (n = 4–5 mice in each group). *P<0.05, **P<0.01, ***P<0.001, vs. WT.