Table 2. Associations of COVID-19 severity, medical history, demographics, and days since SARS-CoV-2 diagnosis with nAb responses among the convalescent participants in Americas (n = 329).
| Response Rate | Titer | |||||||
|---|---|---|---|---|---|---|---|---|
| OR+ | 95% CI | p-value | q-value | GMR* | 95% CI | p-value | q-value | |
| ID50 | ||||||||
| COVID-19 Severity (Overall) | - | - | <0.001 | - | - | <0.001 | ||
| Symp outpatient vs Asymp | 3.74 | [1.45, 9.99] | 0.007 | 0.031 | 5.66 | [3.17, 10.11] | <0.001 | <0.001 |
| Hospital vs Symp outpatient | 4.39 | [1.5, 14.4] | 0.009 | 0.031 | 3.95 | [2.48, 6.29] | <0.001 | <0.001 |
| Diabetes | 3.98 | [1.08, 19.05] | 0.056 | 0.145 | 2.36 | [1.3, 4.28] | 0.005 | 0.015 |
| Hypertension | 0.16 | [0.06, 0.42] | <0.001 | 0.003 | 0.5 | [0.31, 0.82] | 0.006 | 0.015 |
| Age (>55 vs 18–55) | 3.46 | [1.42, 9.33] | 0.009 | 0.031 | 2.33 | [1.54, 3.52] | <0.001 | <0.001 |
| Sex at Birth (Male vs Female) | 1.23 | [0.56, 2.72] | 0.61 | 0.802 | 1.52 | [1.02, 2.27] | 0.042 | 0.092 |
| COPD/Emphysema/Asthma | 1.17 | [0.37, 4.25] | 0.802 | 0.802 | 0.87 | [0.46, 1.63] | 0.663 | 0.784 |
| Current Cigarettes/Mari Smoker | 1.21 | [0.38, 4.17] | 0.754 | 0.802 | 0.97 | [0.46, 2.04] | 0.94 | 0.94 |
| Ever Cigarettes/Mari Smoker | 0.57 | [0.25, 1.3] | 0.182 | 0.338 | 0.81 | [0.53, 1.24] | 0.33 | 0.536 |
| Non-His Black vs White | 0.63 | [0.2, 1.99] | 0.426 | 0.693 | 0.92 | [0.45, 1.88] | 0.824 | 0.892 |
| His/Latino vs Non-His White | 4.51 | [0.73, 89.28] | 0.178 | 0.338 | 1.45 | [0.57, 3.71] | 0.438 | 0.62 |
| Others vs Non-His White | 1.39 | [0.27, 10.85] | 0.716 | 0.802 | 1.44 | [0.53, 3.97] | 0.477 | 0.62 |
| BMI (≥30 vs <30) | 1.21 | [0.56, 2.68] | 0.638 | 0.802 | 1.37 | [0.92, 2.04] | 0.123 | 0.229 |
| ID80 | ||||||||
| COVID-19 Severity (Overall) | - | - | <0.001 | - | - | <0.001 | ||
| Symp outpatient vs Asymp | 6.72 | [2.91, 16.32] | <0.001 | <0.001 | 4.14 | [2.68, 6.39] | <0.001 | <0.001 |
| Hospital vs Symp outpatient | 5.06 | [2.09, 13.28] | 0.001 | 0.003 | 3.79 | [2.68, 5.38] | <0.001 | <0.001 |
| Diabetes | 3.35 | [1.09, 12.05] | 0.046 | 0.117 | 1.81 | [1.16, 2.82] | 0.01 | 0.025 |
| Hypertension | 0.32 | [0.14, 0.75] | 0.01 | 0.031 | 0.75 | [0.52, 1.08] | 0.123 | 0.229 |
| Age (>55 vs 18–55) | 3.13 | [1.5, 6.89] | 0.003 | 0.014 | 1.98 | [1.45, 2.69] | <0.001 | <0.001 |
| Sex at Birth (Male vs Female) | 1.48 | [0.76, 2.93] | 0.249 | 0.36 | 1.55 | [1.15, 2.1] | 0.004 | 0.014 |
| COPD/Emphysema/Asthma | 0.86 | [0.33, 2.32] | 0.754 | 0.891 | 1.03 | [0.64, 1.65] | 0.898 | 0.9 |
| Current Cigarettes/Mari Smoker | 2.2 | [0.72, 7.26] | 0.179 | 0.29 | 1.04 | [0.59, 1.81] | 0.9 | 0.9 |
| Ever Cigarettes/Mari Smoker | 0.62 | [0.31, 1.24] | 0.176 | 0.29 | 0.95 | [0.69, 1.3] | 0.75 | 0.9 |
| Non-His Black vs White | 0.96 | [0.34, 2.78] | 0.94 | 0.988 | 1.19 | [0.7, 2.03] | 0.522 | 0.849 |
| His/Latino vs Non-His White | 1.46 | [0.41, 5.73] | 0.568 | 0.739 | 1.12 | [0.55, 2.26] | 0.757 | 0.9 |
| Others vs Non-His White | 1.01 | [0.23, 4.87] | 0.988 | 0.988 | 1.11 | [0.52, 2.36] | 0.794 | 0.9 |
| BMI (≥30 vs <30) | 1.97 | [1, 4] | 0.054 | 0.117 | 1.44 | [1.07, 1.94] | 0.018 | 0.039 |
+Odds ratio.
*Geometric mean ratio.
asymp, asymptomatic; BMI, body mass index; CI, confidence interval; COPD, chronic obstructive pulmonary disease; COVID-19, Coronavirus Disease 2019; His, Hispanic; hospital, hospitalized; mari, marijuana; nAb, neutralizing antibody; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; Symp, symptomatic.
Region and days since SARS-CoV-2 diagnosis were adjusted in the model.
Bold = significant.