Table 1. Radioactivity concentrations in tissues after single intranasal administration of [³H]TTA-121 to male rabbits (dose: 4 U/body).

	Radioactivity concentration (ng eq./g or mL)
Tissue	15 min			45 min			90 min
Prefrontal area	0.275	±	0.047	1.02	±	0.09	1.12	±	0.31
Precuneus	0.313	±	0.069	0.965	±	0.111	1.16	±	0.32
Cerebral cortex*	0.257	±	0.062	0.997	±	0.058	1.12	±	0.26
Olfactory bulb	0.353	±	0.053	1.18	±	0.12	1.13	±	0.22
Striatum	0.260	±	0.029	1.00	±	0.13	0.943	±	0.046
Hippocampus	0.236	±	0.043	0.958	±	0.049	1.03	±	0.25
Thalamus	0.267	±	0.057	0.961	±	0.106	1.06	±	0.35
Hypothalamus	0.279	±	0.097	0.781	±	0.025	0.888	±	0.182
Midbrain	0.308	±	0.086	0.944	±	0.150	1.02	±	0.22
Cerebellum	0.305	±	0.070	1.08	±	0.12	1.32	±	0.32
Medulla oblongata	0.268	±	0.054	0.825	±	0.077	0.938	±	0.192
Pons	0.236	±	0.052	0.839	±	0.107	0.878	±	0.134
Cervical spinal cord	0.178	±	0.051	0.593	±	0.047	0.664	±	0.153
Brain (others)	0.235	±	0.026	0.837	±	0.032	0.933	±	0.205
Whole brain	0.266	±	0.058	0.960	±	0.060	1.07	±	0.25
Plasma	1.09	±	0.19	1.64	±	0.18	1.29	±	0.34
Blood	0.784	±	0.188	1.26	±	0.09	0.938	±	0.220
Trigeminal nerve (part)	0.185	±	0.027	0.771	±	0.116	0.709	±	0.226
Pituitary gland	0.799	±	0.115	3.15	±	0.10	3.49	±	0.16
Esophagus	0.367	±	0.079	2.34	±	0.83	2.03	±	0.69
Trachea	1.42	±	2.06	4.95	±	4.43	1.51	±	0.96
Heart	0.550	±	0.046	1.40	±	0.18	1.45	±	0.35
Lung	1.74	±	1.79	3.16	±	1.52	3.66	±	2.65
Liver	0.469	±	0.063	2.60	±	0.58	3.10	±	0.55
Kidney	1.72	±	0.41	4.00	±	1.04	5.28	±	1.62
Adrenal gland	0.583	±	0.056	2.57	±	0.32	3.30	±	0.72
Spleen	0.719	±	0.077	2.96	±	0.32	3.25	±	0.81
Pancreas	1.35	±	0.29	13.2	±	3.2	13.5	±	6.6
Testis	0.202	±	0.021	1.08	±	0.12	1.30	±	0.36
Stomach	0.915	±	0.117	5.21	±	2.29	6.55	±	4.99
Small intestine	0.230	±	0.017	2.25	±	0.65	2.72	±	1.42
Large intestine	0.228	±	0.064	1.57	±	0.48	2.12	±	0.83

*: Except prefrontal area and precuneus

Data are expressed as the mean values ± SD of three animals.