Table 2. Radioactivity concentrations in tissues after single intranasal administration of [³H]control formulation to male rabbits (dose: 4 U/body).

	Radioactivity concentration (ng eq./g or mL)
Tissue	15 min			45 min			90 min
Prefrontal area	0.104	±	0.009	0.199	±	0.027	0.360	±	0.091
Precuneus	0.140	±	0.048	0.242	±	0.098	0.274	±	0.138
Cerebral cortex*	0.141	±	0.058	0.198	±	0.049	0.316	±	0.155
Olfactory bulb	0.435	±	0.029	0.472	±	0.169	1.07	±	0.93
Striatum	0.0994	±	0.0196	0.178	±	0.035	0.370	±	0.226
Hippocampus	0.113	±	0.018	0.180	±	0.032	0.298	±	0.160
Thalamus	0.112	±	0.028	0.159	±	0.035	0.302	±	0.153
Hypothalamus	0.114	±	0.023	0.169	±	0.056	0.308	±	0.079
Midbrain	0.0903	±	0.0406	0.205	±	0.082	0.281	±	0.142
Cerebellum	0.164	±	0.026	0.203	±	0.055	0.569	±	0.487
Medulla oblongata	0.0995	±	0.0123	0.166	±	0.058	0.413	±	0.299
Pons	0.111	±	0.036	0.165	±	0.067	0.286	±	0.143
Cervical spinal cord	0.0875	±	0.0306	0.135	±	0.023	0.249	±	0.148
Brain (others)	0.109	±	0.006	0.219	±	0.086	0.253	±	0.122
Whole brain	0.133	±	0.018	0.195	±	0.048	0.355	±	0.193
Plasma	0.233	±	0.043	0.384	±	0.238	0.271	±	0.107
Blood	0.175	±	0.047	0.421	±	0.286	0.376	±	0.227
Trigeminal nerve (part)	0.441	±	0.527	0.309	±	0.166	0.221	±	0.131
Pituitary gland	0.554	±	0.102	0.931	±	0.431	1.70	±	0.38
Esophagus	0.710	±	0.506	8.00	±	6.53	8.05	±	6.65
Trachea	15.4	±	13.8	28.1	±	9.4	21.3	±	18.3
Heart	0.357	±	0.216	0.660	±	0.409	0.584	±	0.301
Lung	10.2	±	2.0	20.2	±	4.6	24.8	±	27.9
Liver	0.190	±	0.028	0.636	±	0.076	1.33	±	0.70
Kidney	0.360	±	0.105	0.935	±	0.100	1.44	±	0.75
Adrenal gland	0.186	±	0.073	0.681	±	0.115	1.11	±	0.45
Spleen	0.213	±	0.092	0.691	±	0.146	1.12	±	0.48
Pancreas	0.372	±	0.112	2.76	±	0.53	5.77	±	3.59
Testis	0.0599	±	0.0164	0.224	±	0.019	0.437	±	0.209
Stomach	0.317	±	0.048	0.840	±	0.136	2.29	±	0.75
Small intestine	0.0932	±	0.0345	0.460	±	0.112	1.43	±	0.80
Large intestine	0.0904	±	0.0281	0.436	±	0.091	0.833	±	0.354

*: Except prefrontal area and precuneus

Data are expressed as the mean values ± SD of three animals.