Table 3. PK parameters in plasma and whole brains after single intranasal administration of [³H]TTA-121 and [³H]control formulation to male rabbits (dose: 4 U/body).

	[3H]TTA-121	[3H]Control formulation	Ratio
Cmax (ng eq./mL or g)
Plasma	1.64	0.384	4.3
Whole brain	1.07	0.355	3.0
AUCt (ng eq.·min/mL or g)
Plasma	115.05	25.74	4.5
Whole brain	66.06	18.29	3.6