Table 4. Association of SNPs with GDM risk using a recessive model (unadjusted odds ratios; OR, Breslow-Day Test; BD, Mantel-Haenszel formula; MH).
| Filipino | Japanese | PI | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | OR | P | OR | P | OR | P | BD_FJPI | OR. mh | Low. B | Up. B | ||||||
| ADCY5 | rs2877716 | 1.13 | ( | 0.99 | ) | NA | ( | NA | ) | NA | ( | NA | ) | NA | 0 | 0 | 0 |
| ARAP 1 | rs11603334 | 2.39 | ( | 0.544 | ) | NA | ( | NA | ) | 2.85 | ( | 0.471 | ) | 0.931 | 2.605 | 0.364 | 18.643 |
| CDKAL1 | rs7754840 | 0.82 | ( | 0.375 | ) | 1.38 | ( | 0.441 | ) | 1.33 | ( | 0.436 | ) | 0.366 | 0.997 | 0.71 | 1.4 |
| CDKN2A/2B | rs10811661 | 0.63 | ( | 0.167 | ) | 0.36 | ( | 0.031 | ) | 1.17 | ( | 0.701 | ) | 0.18 | 0.667 | 0.425 | 1.047 |
| DGKB | rs2191349 | 1.48 | ( | 0.327 | ) | 0.94 | ( | 0.903 | ) | 0.31 | ( | 0.204 | ) | 0.32 | 1.057 | 0.587 | 1.903 |
| EXT2 | rs1113132 | 0.73 | ( | 0.392 | ) | 1.52 | ( | 0.201 | ) | 1.14 | ( | 0.332 | ) | 0.131 | 1.03 | 0.652 | 1.627 |
| FTO | rs8050136 | 1.06 | ( | 0.923 | ) | 2.56 | ( | 0.267 | ) | 1.95 | ( | 0.484 | ) | 0.662 | 1.514 | 0.655 | 3.499 |
| G6PC2 | rs3755157 | 1.04 | ( | 0.898 | ) | 1.49 | ( | 0.374 | ) | 1.19 | ( | 0.621 | ) | 0.792 | 1.168 | 0.788 | 1.732 |
| G6PC2 | rs560887 | 1.13 | ( | 0.99 | ) | NA | ( | NA | ) | 1.14 | ( | 1 | ) | 0.372 | 0.518 | 0.06 | 4.461 |
| G6PC2 | rs16856187 | 1.04 | ( | 0.898 | ) | 1.44 | ( | 0.406 | ) | 1.36 | ( | 0.387 | ) | 0.745 | 1.198 | 0.821 | 1.749 |
| GCK | rs4607517 | 1.02 | ( | 0.969 | ) | 1.06 | ( | 0.935 | ) | 0.48 | ( | 0.46 | ) | 0.794 | 0.919 | 0.438 | 1.929 |
| GCKR | rs780094 | 0.76 | ( | 0.268 | ) | 1.10 | ( | 0.785 | ) | 1.35 | ( | 0.6 | ) | 0.521 | 0.9 | 0.616 | 1.316 |
| HHEX | rs1111875 | 1.13 | ( | 0.798 | ) | 1.1 | ( | 0.857 | ) | 1.15 | ( | 0.729 | ) | 0.998 | 1.128 | 0.679 | 1.873 |
| HHEX | rs7923837 | 1.81 | ( | 0.448 | ) | 1.65 | ( | 0.595 | ) | 1.3 | ( | 0.592 | ) | 0.923 | 1.456 | 0.703 | 3.013 |
| IGFBP2 | rs4402960 | 0.75 | ( | 0.435 | ) | 0.37 | ( | 0.156 | ) | 0.84 | ( | 0.826 | ) | 0.679 | 0.665 | 0.361 | 1.224 |
| KCNQ1 | rs2237892 | 0.55 | ( | 0.03 | ) | 0.78 | ( | 0.565 | ) | 0.82 | ( | 0.736 | ) | 0.726 | 0.634 | 0.412 | 0.977 |
| KCNQ1 | rs2237895 | 2 | ( | 0.015 | ) | 0.69 | ( | 0.517 | ) | 1.64 | ( | 0.404 | ) | 0.25 | 1.604 | 1.025 | 2.508 |
| MADD | rs10501320 | NA | ( | NA | ) | NA | ( | NA | ) | NA | ( | NA | ) | NA | 0 | 0 | 0 |
| MTNR 1B | rs10830963 | 0.39 | ( | < .001 | ) | 0.61 | ( | 0.15 | ) | 0.7 | ( | 0.296 | ) | 0.339 | 0.506 | 0.356 | 0.72 |
| PKN2 | rs6698181 | 0.59 | ( | 0.325 | ) | 1.89 | ( | 0.117 | ) | 1.14 | ( | 1 | ) | 0.185 | 1.2 | 0.653 | 2.205 |
| SLC30A8 | rs13266634 | 0.79 | ( | 0.301 | ) | 0.55 | ( | 0.23 | ) | 2.77 | ( | 0.005 | ) | 0.004 | |||
| TCF7L2 | rs11196205 | 1.13 | ( | 0.99 | ) | NA | ( | NA | ) | 1.14 | ( | 0.57 | ) | 0.363 | 0.432 | 0.052 | 3.622 |
| TCF7L2 | rs12255372 | NA | ( | NA | ) | NA | ( | NA | ) | 1.14 | ( | 1 | ) | NA | 0 | 0 | 0 |
| TCF7L2 | rs7903146 | 1.13 | ( | 0.296 | ) | NA | ( | NA | ) | 1.14 | ( | 0.345 | ) | 0.028 | |||
| TCF7L2 | rs7901695 | NA | ( | NA | ) | NA | ( | NA | ) | 1.14 | ( | 0.571 | ) | NA | 0 | 0 | 0 |
BD-FJPI = Breslow Day Test for Filipino, Japanese and Pacific Islander. SNPs with significant unadjusted OR p values (p<0.05) are shown in blue. SNPs with significant Breslow-Day test p values (p<0.05) are shown in green. SNPs with values from Mantel-Haenszel formula significantly different from 1.0 are shown in red.