Table 4.
Correlations Between Baseline Characteristics and Vascular Density in MFS Patients Using Generalized Estimating Equations for Logistic Regression Analysis
| Central VD | Para-Area VD | Full-Area VD | Para-Nasal-Area VD | Para-Temporal-Area VD | Para-Superior-Area VD | Para-Inferior-Area VD | ||||||||
| β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |
| Age, years | −0.660 (−0.971 to −0.355) | <0.001 * | 0.151 (−0.146 to 0.448) | 0.320 | 0.060 (−0.232 to 0.352) | 0.686 | 0.159 (−0.253 to 0.570) | 0.450 | 0.047 (−0.263 to 0.357) | 0.766 | 0.157 (−0.190 to 0.505) | 0.375 | 0.105 (−0.239 to 0.450) | 0.549 |
| Sex (male %) | −1.650 (−3.182 to −0.120) | 0.035 | −2.196 (−3.607 to −0.784) | 0.002 * | −2.144 (−3.545 to −0.743) | 0.003 * | −2.793 (−4.771 to −0.815) | 0.006 | −2.211 (−3.566 to −0.857) | 0.001 * | −1.873 (−3.504 to −0.241) | 0.024 | −1.676 (−3.547 to 0.196) | 0.079 |
| BCVA (logMAR [Snellen]) | −3.248 (−5.426 to 1.070) | 0.003 * | −0.973 (−2.685 to 0.738) | 0.265 | −1.230 (−2.920 to 0.461) | 0.154 | −1.970 (−4.685 to 0.744) | 0.155 | −1.046 (−2.907 to 0.815) | 0.271 | −0.341 (−2.501 to 1.819) | 0.757 | −2.161 (−4.428 to 0.106) | 0.062 |
| SE, D | −0.048 (−0.146 to 0.049) | 0.329 | −0.062 (−0.139 to 0.015) | 0.113 | −0.059 (−0.136 to 0.019) | 0.137 | −0.130 (−0.255 to −0.005) | 0.041* | −0.079 (−0.160 to 0.002) | 0.056 | −0.117 (−0.243 to 0.008) | 0.067 | 0.007 (−0.080 to 0.094) | 0.866 |
| Intraocular pressure, mmHg | −0.080 (−0.265 to 0.105) | 0.396 | 0.023 (−0.151 to 0.198) | 0.794 | 0.018 (−0.153 to 0.189) | 0.839 | 0.111 (−0.097 to 0.319) | 0.295 | 0.026 (−0.148 to 0.200) | 0.769 | 0.009 (−0.211 to 0.229) | 0.936 | −0.052 (−0.256 to 0.152) | 0.616 |
| AL, mm | 0.709 (0.381 to 1.037) | <0.001 * | 0.057 (−0.243 to 0.357) | 0.710 | 0.131 (−0.165 to 0.428) | 0.384 | 0.178 (−0.259 to 0.616) | 0.425 | −0.010 (−0.293 to 0.272) | 0.942 | 0.126 (−0.237 to 0.488) | 0.497 | −0.121 (−0.472 to 0.231) | 0.501 |
| CMT, μm | 0.088 (0.046 to 0.130) | <0.001 * | −0.005 (−0.038 to 0.028) | 0.768 | 0.006 (−0.028 to 0.040) | 0.740 | −0.041 (−0.097 to 0.016) | 0.156 | −0.022 (−0.059 to 0.015) | 0.244 | 0.020 (−0.029 to 0.069) | 0.430 | −0.021 (−0.066 to 0.025) | 0.376 |
| Ganglion cell layer, μm | 0.070 (−0.043 to 0.182) | 0.227 | 0.087 (−0.046 to 0.219) | 0.201 | 0.086 (−0.046 to 0.218) | 0.201 | 0.075 (−0.074 to 0.224) | 0.322 | 0.091 (−0.025 to 0.207) | 0.125 | 0.108 (−0.011 to 0.228) | 0.076 | 0.082 (−0.079 to 0.243) | 0.318 |
| vCD (%) | 1.583 (−2.110 to 5.276) | 0.401 | −1.247 (−3.735 to 1.242) | 0.326 | −0.983 (−3.475 to 1.509) | 0.440 | −0.181 (−4.105 to 3.744) | 0.928 | −1.504 (−4.433 to 1.426) | 0.314 | −2.153 (−5.944 to 1.638) | 0.266 | −2.257 (−6.048 to 1.534) | 0.243 |
| Average RNFL, μm | −0.053 (−0.167 to 0.060) | 0.359 | 0.029 (−0.077 to 0.135) | 0.593 | 0.021 (−0.079 to 0.121) | 0.682 | 0.071 (−0.055 to 0.197) | 0.268 | −0.003 (−0.095 to 0.088) | 0.944 | 0.041 (−0.096 to 0.178) | 0.562 | 0.000 (−0.135 to 0.134) | 0.995 |
| Superior RNFL, μm | 0.023 (−0.025 to 0.072) | 0.347 | −0.011 (−0.048 to 0.026) | 0.577 | −0.007 (−0.043 to 0.029) | 0.714 | −0.014 (−0.059 to 0.031) | 0.544 | −0.002 (−0.034 to 0.030) | 0.909 | −0.021 (−0.068 to 0.026) | 0.375 | −0.007 (−0.050 to 0.036) | 0.748 |
| Inferior RNFL, μm | 0.050 (−0.010 to 0.110) | 0.100 | 0.012 (−0.046 to 0.070) | 0.680 | 0.015 (−0.040 to 0.070) | 0.588 | 0.002 (−0.062 to 0.065) | 0.959 | 0.038 (−0.021 to 0.097) | 0.204 | −0.005 (−0.073 to 0.063) | 0.880 | 0.035 (−0.033 to 0.102) | 0.311 |
| Degree of lens dislocation (%) (severe) | 1.859 (−1.980 to 5.697) | 0.343 | −0.731 (−3.985 to 2.522) | 0.660 | −0.393 (−3.470 to 2.685) | 0.803 | 0.563 (−4.681 to 5.807) | 0.833 | −3.042 (−7.566 to 1.483) | 0.188 | −3.533 (−8.984 to 1.918) | 0.204 | 1.300 (−2.925 to 5.524) | 0.547 |
| Aortic diameter sinuses of Valsalva, mm | 0.200 (−0.085 to 0.486) | 0.169 | −0.232 (−0.513 to 0.049) | 0.105 | −0.187 (−0.466 to 0.092) | 0.188 | −0.202 (−0.546 to 0.143) | 0.817 | −0.205 (−0.468 to 0.058) | 0.126 | −0.241 (−0.555 to 0.073) | 0.133 | −0.182 (−0.499 to 0.135) | 0.260 |
| Z score | −0.150 (−0.880 to 0.580) | 0.687 | 0.723 (−0.040 to 1.486) | 0.063 | 0.632 (−0.125 to 1.389) | 0.102 | 0.493 (−0.378 to 1.364) | 0.267 | 0.899 (0.207 to 1.590) | 0.011 | 0.724 (−0.046 to 1.494) | 0.066 | 0.586 (−0.303 to 1.474) | 0.196 |
| EF | 0.089 (−0.018 to 0.197) | 0.103 | 0.09 (0.003 to 0.117) | 0.042 | 0.094 (0.006 to 0.182) | 0.036 | 0.076 (−0.028 to 0.180) | 0.154 | 0.132 (0.041 to 0.223) | 0.004 | 0.073 (−0.029 to 0.175) | 0.162 | 0.062 (−0.037 to 0.161) | 0.217 |
*
P value significant after applying the corrected alpha threshold of 0.003. Bold indicates significant values.