Figure 5.

Expression of ADAMTS5 and versican in human hearts. A, Single-cell RNA sequencing data in human cardiac tissue. Versican expression was restricted to cardiac fibroblasts (CFs) and a subset of myeloid cells. ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) was expressed by CFs (FB). B, FB1 showed high ADAMTS5 but low versican expression. The opposite was the case for FB2. Thus, there was an inverse association between the expression of ADAMTS5 and of its main substrate versican in CFs of human hearts. C, Aggregated expression for ADAMTS5 and VCAN in the cardiac fibroblast populations FB1 and FB2, displaying both levels of expression and the percentage of cells in which each transcript expression was detected. CM indicates cardiomyocyte.