Figure 7.

Effect of β-blockers on cardiac extracellular matrix remodeling. A, Abundance pattern-based clustering of extracellular matrix (ECM) proteins. A dense cluster of interstitial, fibroblast-secreted ECM proteins comprised the majority of those altered with β-blocker usage (circled in black). Serum-derived proteins were excluded from this analysis. B, Principal component analyses (PCAs) based on clinical variables or ECM proteomics. Patients with or without β-blocker administration shared similar clinical characteristics. Their ECM proteomic profiles, however, were distinct. C, A comparison of PCA values for ECM proteomics profiles between patients with or without β-blocker administration detected significant differences according to PCA1. The limma package was used for P value calculation using the Ebayes algorithm and correcting for age and sex.