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. 2021 Dec 6;12:754554. doi: 10.3389/fphar.2021.754554

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Copyright © 2021 Lin, Xu, Wu, Qi, Xu, Liu, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The SIRT1 and p53 protein expressions in the liver tissues of each group (×400). SIRT1 (A1–F1), A1: NC group, B1: D–gal group, C1: low–dose group, D1: medium–dose group, E1: high–dose group, F1: Vc group; p53 (A2–F2), A2: NC group, B2: D–gal group, C2: low–dose group, D2: medium–dose group, E2: high–dose group, F2: Vc group. G: The SIRT1 positive staining area in each group; H: The p53 positive staining area in each group. Compared with normal group, #: p < 0.05; ##: p < 0.01; Compared with D–gal group, *: p < 0.05, **: p < 0.01. NC: normal control group; D–gal: D–gal model group; SL: low–dose SDE group; SM: medium–dose SDE group; SL: high–dose SDE group; Vc: Vc positive control group.