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The penetration of liposomes containing SME (150 μg/mL) and/or DNS/PK (25 and 10 μg/mL) through Cutibacterium acnes biofilm: (A) the penetration of Bodipy FL C16-stained liposomes into the dextran-stained biofilm observed by confocal microscopy; and (B) the penetration depth of Bodipy FL C16-stained liposomes quantified from confocal microscopy. All data are presented as the mean of three experiments±S.E.M.
