Table 1.

Patient anthropometrics, median of opioid consumption, and pain origin, in accordance to the diagnosis.

Variable	Methadone (n = 175)	Morphine (n = 87)	Total (n = 262)
Gender* n (%)
Female	116 (66.3%)	49 (55.7%)	165 (62.7%)
Male	59 (33.7%)	38 (44.3%)	98 (37.3%)
Age†	62.1 (±15.5)	55.5 (±12.02)	59.2 (±14.9)
Opioid consumption‡	12.6 (±13.3)	47.4 (±57.6)	—
Cancer-related pain§	17 (9.7%)	42 (48.2%)	59 (22.5%)
Pain origin‖
Nociceptive¶	53 (30.2%)	51 (56.0%)	104 (39.7%)
Neuropathic#	41 (23.4%)	16 (18.3%)	57 (21.7%)
Mixed**	61 (34.8%)	17 (19%)	78 (29.8%)
Nociplastic††	19 (10.8%)	2 (2.2%)	21 (8%.0%)
Missing data‡‡	1 (0.8%)	1 (4.5%)	2 (0%.8%)

^*P = 0.106 (Fisher test).

^†Mean (standard deviation), P = 0.0002 (t test).

^‡Mean during the entire follow-up period (standard deviation), value expressed in mg.

^§P < 0.0001 (Fisher test).

^‖Mean; mixed pain = neuropathic and nociceptive components, P values (Fisher test).

^¶P = <0.0001.

^#P = 0.42.

^**P = 0.014.

^††P = 0.015.

^‡‡P = 1.