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Colitis induction in SCID mice. Experimentally, the adoptive T-cell transfer model induces chronic small bowel and colonic inflammation, which resembles some key aspects of human IBD. To generate the model, CD4+CD45RBhigh T-cells (which are CD25–) are sorted and isolated from donor BALB/c splenocytes. Cell transfer to a syngeneic immunodeficient SCID or RAG2–/– recipient generates a model with primary inflammation in the colon.
