Table 1.
Summary of studies included in the meta-analysis.
| Study | Country | Animals | Model (type and level of SCI) | Groups (n) | Administration time; treatment duration | Motor function; evaluation time |
|---|---|---|---|---|---|---|
| Wang et al. (2016) | China | Female SD rats, 180-220 g | Contusion; T9-10 | A: sham (n = 18) B: SCI+vehicle (n = 18) C: SCI+met (100 mg/kg, ip.) (n = 18) D: SCI+MET-PC (200 mg/kg, ip.) (n = 18) |
Group C: instantly, 3 d Group D: pretreated for 2 weeks before SCI |
BBBs; 0, 1, 3, 7, 14, 21, 28 d |
| Zhang et al. (2017a) | China | Female SD rats, 220-250 g | Compression; T9 | A: SCI+vehicle (n = 5) B: SCI+met (50 mg/kg, ip.) (n = 5) |
Instantly; 14 d | BBBs; 1, 3, 7, 14 d |
| Zhang et al. (2017b) | China | Female SD rats, 220-250 g | Compression; T9 | A: SCI+vehicle (n = 5) B: SCI+met (50 mg/kg, ip.) (n = 5) |
Instantly; 28 d | BBBs; 1, 3, 7, 14, 21, 28 d |
| Guo et al. (2018) | China | Female SD rats, 200-240 g | Contusion; T9-10 | A: sham (n = 20) B: SCI+vehicle (n = 20) C: SCI+met (10 mg/kg, ip.) (n = 20) |
Instantly; 3 d | BBBs; 0, 1, 3, 7, 14, 21, 28 d |
| Afshari et al. (2018) | Iran | Male SD rats, 240-260 g | Contusion; T9 | A: sham (n = 8) B: SCI+vehicle (n = 8) C: SCI+met (10 mg/kg, ip.) (n = 8) D: SCI+met (50 mg/kg, ip.) (n = 8) E: SCI+met (100 mg/kg, ip.) (n = 8) F: SCI+minocycline (90 mg/kg, ip.) (n = 8) |
Instantly; 1 d | BBBs; 0, 1, 3, 7, 14, 21, 28 d |
| Zhang et al. (2020) | China | Male SD rats, 180-200 g | Contusion; T8-9 | A: sham+vehicle (n = 18) B: SCI+vehicle (n = 18) C: SCI+met (50 mg/kg, ip.) (n = 18) D: SCI+met+XAV939 (0.4 mg/kg, ip.) (n = 18) E: SCI+methylprednisolone (30 mg/kg, ip.) (n = 18) |
Instantly; 14 d | BBBs; 0, 1, 3, 7, 14, 21, 28 d |
| Wang et al. (2020) | China | Female SD rats, 220-250 g | Compression; T9 | A: sham (n = 20) B: SCI+vehicle (n = 20) C: SCI+met (50 mg/kg, ip.) (n = 20) D: SCI+met+LY294002 (1.2 mg/kg, ip.) (n = 20) |
Instantly; 7, 14 d | BBBs; 1, 3, 5, 7, 14 d |
SD: Sprague-Dawley; met: met; SCI: spinal cord injury; ip.: intraperitoneal injection; BBBs: Basso, Beattie, and Bresnahan scale; T: thoracic vertebrae; d: day; MET-PC: metformin preconditioning.