Table 2.
Risk of bias in included studies accessed by SYRCLE's RoB tool.
| Study | Risk of bias for each item∗ assessed | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selection bias | Performance bias | Detection bias | Attrition bias | Reporting bias | Other biases | |||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
| Afshari et al. (2018) | Unclear | Yes | Unclear | Yes | Unclear | Unclear | Yes | Unclear | Yes | Unclear | Unclear | Yes | Yes | Unclear |
| Guo et al. (2018) | Unclear | Yes | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Unclear | Unclear | Yes | Yes | Unclear |
| Wang et al. (2016) | Unclear | Yes | Unclear | Unclear | Unclear | Unclear | Yes | Unclear | Yes | Unclear | Unclear | Yes | Yes | Yes |
| Wang et al. (2020) | Unclear | Yes | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Unclear | Unclear | Yes | Yes | Unclear |
| Zhang et al. (2017a) | Unclear | Yes | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Yes | Unclear | Yes | Yes | Unclear |
| Zhang et al. (2017b) | Unclear | Yes | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Yes | Unclear | Yes | Yes | Unclear |
| Zhang et al. (2020) | Yes | Yes | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Yes | Unclear | Unclear | Yes | Yes | Unclear |
∗1: sequence generation; 2: baseline characteristics; 3: allocation concealment; 4: random housing; 5: blinding; 6: random outcome assessment; 7: blinding; 8: complete outcome data; 9: selective outcome reporting; 10: free of contamination; 11: free of inappropriate influence of funders; 12: free of the unit of analysis errors; 13: design-specific risks of bias absent; 14: new animals added to replace drop-outs.