Table 3.
Heart function and markers of cell injury in DCD hearts by treatment received
| DCD Control |
DCD Inhibition Prior to DCD Early Intervention |
DCD Inhibition at Reperfusion Late Intervention |
||||
|---|---|---|---|---|---|---|
| N=10 | IL-1Ra N = 13 |
IL-18BP N = 8 |
IL-1Ra N = 8 |
IL-18BP N = 9 |
IL-1Ra AND IL-18BP N = 5 |
|
| Functional Data | ||||||
| Heart Rate b/min; Median (Q1-Q3) | 399(381–409) | 421(398–447) | 447(419–469) | 416(393–427) | 441(426–457) | 420(367–434) |
| Perfusion rate ml/min; Median (Q1-Q3) | 1.9(1.7–2.0) | 2.1(1.8–2.4) | 2.8(2.4–3.2) | 2.2(2.0–2.4) | 2.5(2.4–2.7) | 2.0(1.6–2.2) |
| Developed pressure mmHg; Median (Q1-Q3) | 77(74–93)a | 101(86–120)a | 89(86–115)a | 82(80–107) | 114(90–119)a | 98(92–114)a |
| Rate Pressure Product; Median (Q1-Q3) | 30744(23091–38180) | 41203(32553–48944) | 38309(37064–51247)a | 34832(31666–43698) | 46072(32613–50139)a | 32375(26415–39335) |
| Rate of positive developed pressure dt/dp mmHg/ms; Median (Q1-Q3) | 3167(2477–3415) | 3186(2233–5578) | 4634(4039–5776)a | 2839(2126–3736) | 4836(4281–5150)a | 5357(5266–5447)a |
| Rate of negative developed pressure −dt/dp mmHg/ms; Median (Q1-Q3) | −2113(−2790–−1884) | −3070(−3402–−2442)a | −2938(−3657–−2784)a | −2909(−3197–−2600) | −3664(−4117–−2728)a | −3496(−3890–−2988)a |
| Makers of myocyte damage | ||||||
| Eluate troponin level ng/ml; Median (Q1-Q3) | 7.74(5.67–9.65) | 8.37(5.80–9.02) | 3.87(2.89–4.54)a | 5.39(4.29–8.58) | 4.25(3.23–5.17)a | 2.30(1.99–2.94)a |
| TUNEL assay; Median (Q1-Q3) | 1.49(1.35–2.79) | 1.24(1.09–1.88) | 0.55(0.44–0.72) | 1.99(1.28–2.82) | 0.86(0.75–0.87)a | 1.03(0.66–1.37) |
a
P<0.05 vs DCD control