Extended Data Fig. 7. PCC1 alleviates physical dysfunction of animals transplanted with senescent cells.
(a) Maximal walking speed (relative to the baseline) of 5-month-old C57BL/6 J males at different time points post transplantation of 1 ×106 SEN stromal cells and treatment with PCC1 or vehicle (V). (b) Hanging endurance (measured as sec x g) of 5-month-old C57BL/6 J males at different time points as described in (a). Data are representative of 3 biological replicates (n = 10 animals per group). Datasets are displayed as box-and-whisker plots, where a box extends from the 25th to 75th percentile with the median shown as a line in the middle, with whiskers indicating smallest and largest values. For a-b, P values were calculated by two-sided t-test. ^, P > 0.05. *, P < 0.05. **, P < 0.01. ***, P < 0.001.