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. 2021 Dec 20;3(12):1662–1679. doi: 10.1038/s42255-021-00499-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a. PCR for wildtype insulin receptor gene (IR) and Exon 4 deleted insulin receptor allele (IR del) in hypothalamus, cortex, muscle, liver, BAT and WAT of IR^fl/fl Slco1c1-CreERT2^wt/wt (wt) and IR^fl/fl Slco1c1-CreERT2^tg/wt mice (tg) 8 weeks post tamoxifen treatment (n = 4/4). L – Gene Ruler 1 kb Plus DNA ladder. b. ZsGreen reporter protein expression in hypothalamus, cortex, brain vasculature, skeletal muscle, liver, BAT, WAT and pancreas of Rosa26|STOP | ZsGreen^fl/fl Slco1c1-CreERT2^tg/wt mice 2 weeks post tamoxifen treatment. Arrows indicate co-localized ZsGreen signal with lectin positive microvessels. Scale bar: 100 µm, scale bars in insets 30 µm.

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