Extended Data Fig. 8. Tanycyte insulin receptor is not required for leptin access in ARC.

a. Mean food intake during 3-day leptin (3 mg/kg) or NaCl (0.9%) administration in IR^GFP-Tan and IR^ΔTan mice, p(IR^GFP-Tan) = 0.0364, p(IR^ΔTan) = 0.1372, paired, two-sided Student’s t-test. b. Body weight change during 3-day leptin (3 mg/kg) or NaCl (0.9%) administration in IR^GFP-Tan and IRΔTan^ΔTan animals. c. Representative images of pSTAT3 in ARC 20 min post i.p. injection of 3 mg/kg leptin of IR^GFP-Tan and IR^ΔTan animals. Scale bar: 100 µm. c - d. Quantification of pSTAT3 positive cells per side of ARC, n = 5/group. a-b, d. Data are represented as the mean ± SEM.

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