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. 2021 Sep 23;13(2):425–440. doi: 10.1016/j.jcmgh.2021.09.009

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Decreased intestinal expression of microRNAs and increased inflammation in wild-type neonatal mice treated with IRAK and STAT3 inhibitor. (A) microRNA expression in mouse IECs from vehicle or IRAK inhibitor–treated mice were quantified by real-time PCR. DOL-6 wild-type mice were orally administered IRAK inhibitor at 20 mg/kg of body weight once per day for 3 days, then killed for IEC isolation and analysis. (B) Mouse IEC lysates were analyzed by immunoblotting with the indicated antibodies. (C and D) Real-time PCR analysis of expression of microRNA and proinflammatory cytokines in IECs isolated from wild-type mice with 3 days intraperitoneal injection of STATTIC at 2.5 mg/kg of body weight daily from DOL-7. ∗P < .05, ∗∗P < .01. ACTB, actin beta.