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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2021 Aug 15;112(1):222–236. doi: 10.1016/j.ijrobp.2021.08.015

Figure 2:

Figure 2:

Proton RBE for clonogenic cell survival as predicted by an empirical model (equation 2) [4]. Left: RBE as a function of LET at 2 Gy (solid (α/β)x=2 Gy; dashed (α/β)x=10 Gy). The grey area shows the clinically and dosimetrically most relevant region as LET values are typically between 2.5 and 13 keV/μm [21]. Middle: RBE as a function of dose for LET=2.5 keV/μm (solid (α/β)x=2 Gy; dashed (α/β)x=10 Gy). The grey area shows the clinically most relevant region for a standard 2 Gy fractionation, i.e., doses to organs at risk <2Gy. Right: RBE as a function of (α/β)x for a dose of 2 Gy (solid LET=2 keV/μm; dashed LET=10 keV/μm). The grey area shows the clinically most relevant region of (α/β)x=2–10 Gy.