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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2021 Aug 15;112(1):222–236. doi: 10.1016/j.ijrobp.2021.08.015

Figure 4:

Figure 4:

Proton RBE at 1.8 Gy per fraction based on tumor (α/β)x values extracted from clinical data [64–67] (excluding data with negative values) assuming RBE as a function of (α/β)x) as deduced from clonogenic cell survival (equation (2) [4]) and LET estimates [21]. Upper: LET of 2 keV/μm representative for the proximal part of the tumor and likely a minimum conservative RBE; Middle: LET of 4 keV/μm representative for the distal part of the target; Lower: LET of 10 keV/μm as a maximum for the target.