Table 4.
Univariate linear regression analysis to test the association of variables with vaccination response determined by the Roche anti-SARS-CoV-2 S assay in the immunodeficient cohort.
| Variable | Any Response | Stringent Response | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Age (per 10 years) | 1.23 | 0.92-1.66 | 0.167 | 1.02 | 0.76-1.38 | 0.880 |
| Body mass index (per 5 point) | 1.20 | 0.77-1.87 | 0.420 | 1.11 | 0.71-0.73 | 0.633 |
| Interval in days from last B-cell depleting therapy to vaccination up to 365 days (per 30 days)* | 1.41 | 1.13-1.76 | 0.002 | 1.31 | 1.02-1.67 | 0.035 |
| IgA (per 1g/l) | 0.74 | 0.50-1.10 | 0.136 | 1.30 | 0.87-1.93 | 0.199 |
| IgG (per 5g/l) | 0.96 | 0.62-1.49 | 0.848 | 1.43 | 0.90-2.27 | 0.127 |
| IgM (per 1g/l) | 1.32 | 0.83-2.10 | 0.246 | 0.98 | 0.92-1.05 | 0.677 |
| Lymphocytes abs. (per 1 G/l) | 0.94 | 0.81-1.10 | 0.461 | 1.03 | 0.89-1.18 | 0.686 |
| CD3+ cells abs. (per 10/µl) | 1.00 | 0.99-1.01 | 0.693 | 1.00 | 0.99-1.01 | 0.101 |
| CD3+CD8+ cells abs. (per 10/µl) | 1.01 | 0.99-1.02 | 0.143 | 1.00 | 0.99-1.01 | 0.846 |
| CD3+CD4+ cells abs. (per 10/µl) | 0.99 | 0.98-1.01 | 0.403 | 1.01 | 1.00-1.02 | 0.009 |
| CD3−CD16+CD56+ NK cells abs. (per 10/µl) | 0.98 | 0.96-1.01 | 0.139 | 1.01 | 0.99-1.03 | 0.180 |
| CD19+ abs. (per 10/µl) | 0.99 | 0.99-1.01 | 0.401 | 0.99 | 0.99-1.01 | 0.931 |
| CD45+ cells abs. (per 10/µl) | 0.99 | 0.99-1.01 | 0.045 | 1.00 | 0.99-1.01 | 0.653 |
| CD19+IgM+CD38++ transitional B cells abs. (per 1/µl) | 1.17 | 0.97-1.42 | 0.094 | 1.05 | 0.96-1.15 | 0.233 |
| CD19+IgD+CD27- naïve B cells abs. (per 10/µl) | 1.17 | 1.07-1.28 | 0.001 | 1.09 | 1.04-1.14 | <0.001 |
| CD19+IgD+CD27+ pre-switched memory B cells abs. (per 10/µl) |
1.78 | 1.09-2.92 | 0.021 | 1.03 | 0.95-1.11 | 0.480 |
| CD19+IgD-CD27+ switched memory B cells abs. (per 10/µl) |
0.99 | 0.99-1.01 | 0.406 | 0.99 | 0.99-1.00 | 0.957 |
| CD19+CD38-CD21− B cells abs. (per 10/µl) | 0.99 | 0.98-1.01 | 0.512 | 1.00 | 0.99-1.01 | 0.746 |
| CD19+IgM-CD38++ plasmablasts abs. (per 1/µl) | 7.95 | 2.68-23.4 | <0.001 | 1.85 | 1.24-2.74 | 0.002 |
Significant P-values are highlighted in bold type. Any response, any seroconversion; OR, odds ratio; stringent response, total antibody titre ≥1000 U/ml. Abs., absolute count.