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. 2021 Dec 7;11:809410. doi: 10.3389/fonc.2021.809410

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Copyright © 2021 Huang, Zhang, Dong, Chen, Shao and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gain of MRP-7 Expression Correlates with EC Progression. (A) The Oncomine database was used to compare MRP-7mRNA expression between different tumor and normal tissues. Red denotes an increase in MRP-7 expression, while blue denotes a reduction in MRP-7 expression. (B) MRP-7mRNA expression in TCGA EC tissues compared to normal tissues (Oncomine database). (C) Immunohistochemistry images of MRP-7 staining using tissue microarray tissue sections (HPA database). (D) The mRNA levels of MRP-7 in EC and normal tissues were examined using qRT-PCR experiments. (E–G) The expression of MRP-7 mRNA was considerably higher in EC patients with a high tumor grade (E), late-stage disease (F), or deeper myometrial invasion (G). (H) MRP-7 mRNA expression is substantially higher in EC cells than in normal HESC cells. (I) KM plotter database was used to analyze the association between MRP-7 expression and the overall survival of EC patients. ***P < 0.001.