Table 3.

Clinical outcomes in the primary cohorts stratified by ARDS subphenotypes.

	Ventilator-Free Days			In-hospital mortality*
	Hypo-inflammatory	Hyper-inflammatory	P-value	Hypo-inflammatory	Hyper-inflammatory	P-value
VALID AECC	20 (11 – 25)	5 (0 – 20)	< 0.0001	80/457 (18%)	87/167 (52%)	< 0.0001
VALID AECC (NO TRAUMA)	21 (8 – 25)	4 (0 – 18)	< 0.0001	71/315 (23%)	80/137 (58%)	< 0.0001
EARLI AECC	24 (0 – 28)	0 (0 – 23)	< 0.0001	62/211 (29%)	75/124 (60%)	< 0.0001

P- value represent Wilcoxon rank sum test for ventilator free days and chi-squared test for in hospital mortality. AECC = American-European Consensus Conference.

^*Followed up to day 60 in EARLI and to discharge in VALID