Table 1.
Patient and treatment characteristics
| Characteristic | All patients | Patients without symptomatic cardiac events |
Patients with symptomatic cardiac events |
|---|---|---|---|
| No. | 109 | 83 | 26 |
| Median age (range, years) | 58 (36-82) | 57 (39-82) | 62 (36-81) |
| Gender | |||
| Male | 60 (59%) | 43 (52%) | 17 (65%) |
| Female | 49 (41%) | 40 (48%) | 9 (35%) |
| Tumor laterality | |||
| Right | 64 (59%) | 47 (57%) | 17 (65%) |
| Left | 45 (41%) | 36 (43%) | 9 (35%) |
| Stage | |||
| IIIA | 64 (59%) | 47 (57%) | 17 (65%) |
| IIIB | 45 (41%) | 36 (43%) | 9 (35%) |
| ECOG Performance status | |||
| 0 | 70 (64%) | 50 (60%) | 20 (77%) |
| 1 | 39 (36%) | 33 (40%) | 6 (23%) |
| Active/former smoker | |||
| No | 15 (14%) | 13 (16%) | 2 (8%) |
| Yes | 94 (86%) | 70 (84%) | 24 (92%) |
| Median pack years (range) | 37 (5-120) | 35 (13-120) | 43 (5-100) |
| WHO/ISH 10-yr risk | |||
| <10 % | 65 (60%) | 54 (65%) | 11 (42%) |
| 10-20 % | 34 (31%) | 22 (27%) | 12 (46%) |
| ≥20 % | 10 (9%) | 7 (8%) | 3 (12%) |
| CAD | |||
| No | 93 (85%) | 76 (92%) | 17 (65%) |
| Yes | 16 (15%) | 7 (8%) | 9 (35%) |
| Calcifications | |||
| None | 45 (41%) | 42 (51%) | 3 (12%) |
| Low (<0.2 cc) | 31 (28%) | 22 (27%) | 9 (35%) |
| High (≥0.2 cc) | 33 (30%) | 19 (23%) | 14 (54%) |
| Prescribed RT dose | |||
| 70-74 Gy | 84 (77%) | 65 (78%) | 19 (73%) |
| 78-90 Gy | 25 (23%) | 18 (22%) | 7 (27%) |
| Gross tumor volume (median) | 46.1 cc | 47.1 cc | 44.5 cc |
| Heart mean dose (median) | 12.4 Gy | 10.1 Gy | 20.4 Gy |
| Heart V5Gy (median) | 37.6 % | 34.1 % | 55.9 % |
| Heart V30Gy (median) | 17.4 % | 12.1 % | 28.8 % |
| Left ventricle mean dose (median) | 4.0 Gy | 2.9 Gy | 9.5 Gy |
| Left ventricle V5Gy (median) | 18.4 % | 14.2 % | 38.2 % |
| Left ventricle V30Gy (median) | 2.0 % | 0.4 % | 10.3 % |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; WHO/ISH, World Health Organization / International Society of Hypertension; CAD, coronary artery disease; RT, radiotherapy; V5Gy, volume receiving ≥5 Gy; V30Gy, volume receiving ≥30 Gy.
*
Column percentages displayed.