Table 3.

Competing risk-adjusted analyses for symptomatic cardiac events

		Sim Cohort (n=109)		Diagnostic Cohort (n=74)
Characteristic	p	HR	p	HR
Univariable analyses:
Age	0.335	1.02	0.200	1.03
ECOG PS (1 vs. 0)	0.125	0.49	0.526	0.69
Gross tumor volume	0.434	1.00	0.259	1.00
Heart mean dose	0.002	1.03 / Gy	0.010	1.03 / Gy
Left ventricle mean dose	0.032	1.03	0.107	1.03
WHO/ISH 10-yr risk
≥20% (vs. <10%)	0.28	1.98	0.81	1.28
10-20% (vs. <10%)	0.04	2.34	0.04	2.97
CAD	<0.001	3.69	<0.001	5.47
Calcification burden
Any (vs. none)	0.002	6.50	0.007	5.71
High (vs. none)	<0.001	8.10	0.004	7.12
Low (vs. none)	0.015	4.98	0.043	4.35
Multivariable analvses:
Heart mean dose	<0.001	1.05	0.003	1.05
Calcification burden
High (vs. none)	<0.001	10.64	<0.001	9.83
Low (vs. none)	0.005	7.01	0.072	3.99

Abbreviations: ECOG PS, Eastern Cooperative Oncology Group performance status; WHO/ISH, World Health Organization / International Society of Hypertension; CAD, coronary artery disease