Table 1. Known human placental scRNA-seq datasets.
Summary of 424,238 scRNA-seq transcriptomes related to placental biology.
| First Author | Year | Samples | Cells | Data Repository | Platform |
|---|---|---|---|---|---|
| Pavličev | 2017 | term, cesarean-section placentas from two patients | 87 | GEO: GSE87726 | Fluidigm C1 and laser microdissection |
| Tsang | 2017 | term placentas (two female and two male babies) | 20,518 | EBI: EGAS00001002449 | 10X Genomics 3' (v1) |
| Suryawanshi | 2018 | First trimester (6–11 weeks) >14,300 placental villi from eight patients and 6.7k decidual cells from five patients | 14,341 (placental villi), 6,754 (decidua) | BioProject ID: PRJNA492324 | 10X Genomics and Drop-seq |
| Liu | 2018 | first- and second-trimester (8- and 24-week) placental samples | 1,471 | GEO: GSE89497 | SMART-seq2 |
| Vento-Tormo | 2018 | first-trimester (6–11 weeks) placenta (5 patients, 18,547 cells), decidua (11 patients, 40,512), and matched-PBMCs (6 patients, 10,001 cells) | 70,325 | ArrayExpress: E-MTAB-6701 (10x Genomics) and E-MTAB-6678 (SMART-seq2) | SMART-seq2 or 10X Genomics 3' (v2) |
| Pique-Regi | 2019 | term chorioamniotic membranes, placental villi, and basal plate samples (with or without labor at 38–40 weeks) were compared with samples from pre-term labor (33–34 weeks) patients. | 79,906 | NIH dbGAP: phs001886.v1.p1 | 10X Genomics 3' (v2) |
| Pique-Regi | 2020 | snRNA-seq from 32 placental villi and decidual samples collected from in the second or third-trimester | 26,501 | NIH dbGAP: phs001886.v2.p1 | 10X Genomics 3' (v2 3rd trim. or v3 2nd trim.) |
| Sun | 2020 | first-trimester (6–11 weeks) placental villi were analyzed from 6 patients (3 male and 3 female offspring) | 7,245 | GEO: GSE131696 | 10X Genomics 3' (v2) |
| Han | 2020 | chorionic villus cells from a 13-week male and additional placenta cells from a 10 week female | 19,493 | GEO: GSE134355 **700k cells- select (a) placenta and (b) chorionic villus samples. | Microwell-seq |
| Cao | 2020 | 5 males and 6 females estimated at 12–17-weeks | 29,876 | GEO: GSE156793 **4.9M cells- select 11 placenta samples | Sci-RNA-seq3 |
| Saha | 2020 | first-trimester placentas (6 and 7.6 weeks) | 14,603 (independent analysis) | GEO: GSE145036 | 10X Genomics 3' (v, unk.) |
| Guo | 2021 | 24 human 1st- trimester decidual samples (9 RPL and 15 healthy) that were presorted for CD45+ cells | 10,142 (controls) and 8,504 (RPL) | GSA: CRA002181 | 10X Genomics 3' (v2) |
| Yang | 2021 | Full-term placentas collected during caesarean section (2 healthy and 2 GDM) were subject to scRNA-seq | 14,591 (GDM) and 12,629 (control) | GEO: GSE173193 | 10X Genomics 3' (v3) |
| Shannon | 2021 | healthy placental villi from 7 patients during the first-trimester and additional trophoblast organoid cultures | 12,794 (placenta) and 37,996 (organoid) | ArrayExpress: E-MTAB-6701 | 10X Genomics (v, unk) |