Fig. 6. IFN-β played an important role in the DMXAA-induced antitumor response in vivo. The DMXAA and DMXAA+anti-IFN-β groups of BALB/c mice were inoculated with 5×106 CT26 GFP/luciferase cells in the right flank (n=10). One week later, the control (vehicle treated group), DMXAA, and DMXAA+ anti-IFN-β groups were injected with 1×105 CT26 GFP/luciferase cells intraperitoneally. They received an intratumoral injection of HBSS or 500 µg of DMXAA or an intraperitoneal injection of 600 µg of anti-IFN-β every 3 days. (A) In vivo imaging of CT26 GFP/luciferase tumor in BALB/c mice at day 3 after drug treatment. (B) Region of interest of panel A. The results are expressed as mean±SD. *p<0.05. IFN, interferon; HBSS, Hanks Balanced Salt Solution.
