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. 2021 Dec 20;7:399. doi: 10.1038/s41420-021-00766-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Western blotting analysis verified the transfection efficiency of NLRP3 after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively. B qRT-PCR analysis verified the transfection efficiency of NLRP3 after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively. C The expression of IL-1β and IL-18 in the supernatant and lysate of PC3 and LNCaP cell lines were significantly decreased in sh-NLRP3 + recombinant protein caspase-1, not in sh-NLRP3 alone. D The expression of IL-1β and IL-18 in the supernatant and lysate of PC3 and LNCaP cell lines were significantly decreased in ov-NLRP3 + Z-YVAD-FMK, not in ov-NLRP3 alone. E CCK-8 assay detected the proliferation of PCa after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively. F Transwell assay was used to detect the migration ability after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively (magnification: ×40). G TUNEL assay was used to detect the apoptosis after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively (magnification: ×40). H Western Blot was used to detect the expression level of NLRP3 and caspase-1 after sh-NLRP3 + recombinant protein caspase-1 or ov-NLRP3 + Z-YVAD-FMK in PC3 and LNCaP cell lines, respectively. Data are average ± SD, *p < 0.05, **p < 0.01.