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. 2021 Dec 20;7:399. doi: 10.1038/s41420-021-00766-9

Fig. 5. Knockout of NLRP3 inhibited tumorigenic ability in nude mice.

Fig. 5

A Representative pictures of tumor in sh-NC and sh-NLRP3 cell-transplanted mice in PC3 cell line. B Tumor volume growth curves were calculated for different nude mice after injection of sh-NC and sh-NLRP3, respectively. C Tumor weight growth curves were calculated after injection of sh-NC and sh-NLRP3, respectively. D qRT-PCR assay was used to detect the expression level of NLRP3 and caspase-1 in the tumor-forming tissues of nude mice. E Western blot was used to detect the expression level of NLRP3 and caspase-1 in the tumor-forming tissues of nude mice. F Immunohistochemistry was used to detect the expression level of NLRP3 and caspase-1 in the tumor-forming tissues of nude mice with PC3 cells (magnification: ×40). Data are mean ± SD, *p < 0.05, **p < 0.01.