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. 2021 Dec 20;13(1):15. doi: 10.1038/s41419-021-04387-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Changes in the expression of miR-17-5p and miR-93-5p target genes after MYEOV knockdown in two PDAC cell lines (AsPC-1 and PANC-1). The x-axis represents the LFC between MYEOV-knockdown and wild-type PDAC cells. The y-axis represents the cumulative distribution function (CDF) of LFC distribution. In each comparison, all expressed genes (excluding the target genes of cognate miRNAs) were used as the background. The cumulative distribution difference between targets and background genes was estimated using the Kolmogorov-Smirnov test. b The qPCR-based expression levels of miR-17-5p and miR-93-5p upon MYEOV knockdown. c The qPCR-based expression levels of miR-17-5p and miR-93-5p upon treatment with miRNA inhibitors. d, e Cell proliferation as measured by the CCK-8 (d) and colony formation (e) assays in AsPC-1 and PANC-1 cell lines transfected with the miR-17-5p inhibitor, miR-93-5p inhibitor or NC. f, g Cell migration (f) and invasion (g) as determined by scratch assay (40× magnification) and transwell invasion assay (200× magnification), respectively. All n = 3; bar, SEM; *P < 0.05, **P < 0.01 and ***P < 0.001 compared with NC; Student’s t-test.