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. 2021 Dec 20;13(1):13. doi: 10.1038/s41419-021-04474-1

Fig. 7. The effects of inhibiting autophagy and MAP4K4 expression in the sensitivity of cervical cancer cells to cisplatin treatment.

Fig. 7

A Western blotting analysis on the protein levels of SOX6, PARP, caspase 9, p62/SQSTM1 and LC3B in HeLa-HA-SOX6-tet cells treated with or without Dox (4 μg/mL), cisplatin (20 μM) for 48 h and/or Baf A1 (10 nM) for the last 6 h. α-tubulin protein was used as the internal control. B Western blotting analysis on the protein levels of MAP4K4, PARP, Bax, and Bcl-2 in HeLa cells under cisplatin (20 μM) treatment and treated with or without PF-06260933 (3 μM). C The graphical abstract on the mechanism and clinical significance of SOX6-induced autophagy in cervical cancer cells.