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. 2021 Dec 20;7:89. doi: 10.1038/s41522-021-00261-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Stacked bar showing Lactobacillus abundance groups and vaginal microbiome groups (VMG) of women with leukocyte grades of I (0-5 counts/Hp), II (5-15 counts/Hp), III (15-30 counts/Hp) and IV (>30 counts/Hp). b Boxplots showing relative abundance of L. crispatus, L. gasseri, L. iners, L. jenseni, L. delbruecki, and Lactobacillus spp. in women with leukocyte low (grades I and II, green) and high (grades III and IV, red). The bounds of the box represent the first and third quartiles, center line represents the median, and whiskers show min-to-max values. c LDA of differentially abundant taxa and cladogram displaying bacterial clades and nodes identified as differentialy abundance from LDA analysis in vaginal microbiota of women with leukocyte low (grades I-II, green) and high (grades III-IV, red). Statistical significance of categorical variables based on Fisher’s Exact Test and continuous variables based on Kruskal-Wallis Test.