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. 2021 Dec 20;11:24283. doi: 10.1038/s41598-021-03608-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Na_V1.9 is responsible for setting the neuronal resting membrane potential and plays a role in setting the threshold to action potential firing. (A) Increasing Na_V1.9 current density depolarizes iPSC-SN resting membrane potentials (% depolarization = 1.629*e^{0.007674(current density)}) with an r² of 0.5764. (B) Adding Na_V1.9 currents to iPSC-SNs results in a statistically significant reduction in threshold to action potential firing (left, paired t-test p = 0.0043). However, there does not appear to be a strong correlation between the levels of Na_V1.9 current density and the change in threshold (right).