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. 2021 Dec 20;12:7342. doi: 10.1038/s41467-021-26280-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Forest plot; the centre of the error bars show the standard-deviation change in each progression marker, per 1-standard-deviation increase in gene expression, calculated using the Wald ratio (if 1 SNP) or IVW (if >1 SNP). Results are colour-coded by tissue (red = blood, blue = brain tissue) and corrected for the number of genes tested. 95% CI 95% confidence interval, DEPR depression, FDR false discovery rate, HY Hoehn and Yahr, DEPR depression, UPDRS2-4 Unified Parkinson’s Disease Rating Scale parts 2 to 4.