Table 3.
Evidence supporting druggable genes whose expression was significantly associated with a PD progression trait using the Wald ratio or IVW method.
| Gene | PD outcome | Tissue | Sign. with max. lik. | Sign. with MR-Egger | MR-Egger intercept test | Cochran’s Q test | I2 test | pQTL evidence | Coloc |
|---|---|---|---|---|---|---|---|---|---|
| RHD | Dyskinesia | Brain | ✓ | x | ✓ | ✓ | ✓ | ||
| IRAK3 | Dyskinesia | Blood | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Depression | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
| UPDRS part 2 | Blood | ✓ | x | x | ✓ | ✓ | |||
| UPDRS part 4 | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
| ADAM32 | Hoehn and Yahr | Brain | ✓ | x | ✓ | ✓ | ✓ | ||
| LMAN1 | UPDRS part 2 | Blood | ✓ | x | ✓ | ✓ | ✓ | ||
| Dyskinesia | Blood | ✓ | ✓ | x | ✓ | ✓ | |||
| PYGL | UPDRS part 4 | Brain | ✓ | ||||||
| CD177 | Depression | Brain | |||||||
| QDPR | UPDRS part 4 | Blood | ✓ | ✓ | ✓ | x | x | x | |
| STK4 | Hoehn and Yahr | Brain | x | x | x |
✓ pass, x fail, blank not possible to test, coloc colocalization, max. lik. maximum likelihood, MR Mendelian randomization, PD Parkinson’s disease, pQTL protein quantitative trait locus, sign significant, UPDRS Unified Parkinson’s Disease Rating Scale.