Table 2.
HRs and MSTs by rs7631664 genotypes in the discovery, replication, and combined GWAS samplesa.
| Genotypes | N (%) | MST | HR (95% CI)b | P | HR (95% CI)c | P |
|---|---|---|---|---|---|---|
| Discoveryd | 1.60 (1.32–1.94) | 1.77 × 10−6 | 1.59 (1.31–1.93) | 2.54 × 10−6 | ||
| AA | 962 (71.5) | 88 | ||||
| AG | 354 (26.3) | 53 | ||||
| GG | 29 (2.2) | 46 | ||||
| Replication | 1.56 (1.24–1.95) | 1.23 × 10−4 | 1.45 (1.15–1.82) | 1.45 × 10−3 | ||
| AA | 540 (68.9) | 78 | ||||
| AG | 224 (28.6) | 53 | ||||
| GG | 20 (2.6) | 19 | ||||
| Combined | 1.58 (1.36–1.83) | 8.90 × 10−10 | 1.53 (1.32–1.78) | 1.62 × 10−8 | ||
| AA | 1502 (70.5) | 86 | ||||
| AG | 578 (27.1) | 53 | ||||
| GG | 49 (2.3) | 38 |
HR hazard ratio, MST median survival time (months).
aGenotypes of rs7631664 were extracted from directly genotyping data.
bHR (95% CI). HR and P value was calculated using multivariable-adjusted Cox regression under a log-additive genetic model, adjusting for the top three principal components of population stratification.
cCox regression model was further adjusted by age and clinical stage.
dOne patient with missing genotype of rs7631664 in SOCS-1.