Table 2.
MS analysis of identified proteins in cells reprogrammed with c-MYC.
| (i) Proteins enriched more than two-fold in c-MYC-WT compared with MYCL-WT (SeV) | |||||
|---|---|---|---|---|---|
| ATXN7L3B | TIMM21 | SLC2A3 | CA14 | CRLF3 | SYT6 |
| TMEM161A | MTM1 | METTL15 | NKAP | CDS2 | MRS2 |
| MARS2 | ERCC2 | TDP1 | MFAP4 | ANAPC16 | CARS2 |
| NOLC1 | IGHMBP2 | MRPL34 | FECH | PARP2 | ING1 |
| ADNP2 | STEAP3 | AK6 | PDZD8 | EPB41L5 | PEX16 |
| ZER1 | CKS1B | GGPS1 | DBNDD1 | MIEF1 | FUCA1 |
| ADSSL1 | POTEJ | TMEM209 | CCNL2 | TOP3A | ULK1 |
| MGA | FAM162A | AMMECR1 | ISG20L2 | CEP78 | NOM1 |
| PAPD4 | PROCR | IFRD2 | LRRC41 | UBR3 | PHF3 |
| RIN1 | SPPL2B | ARAF | DNM2 | HPS5 | PSEN1 |
| PARD3 | ARHGEF16 | RHPN2 | PRPF18 | SEMA4C | RPUSD3 |
| NYNRIN | ARHGEF7 | VRTN | PHF10 | DMD | RPL26L1 |
| RANBP6 | CNOT4 | TSPYL5 | CDC25C | REEP4 | FADD |
| INPP5F | ZBTB7A | GPN3 | RBPMS2 | BRAF | ORC6 |
| CACNA2D2 | AP1B1 | NCAPD3 | RRP8 | MASTL | POLR2M |
| CASC3 | NCL | C1orf174 | LRRC14 | SLC27A3 | ACSF3 |
| DHRS11 | RBM23 | WDR55 | CAMK4 | NDRG3 | ALS2 |
| NOVA1 | SOX3 | CLCN7 | EHMT1 | C7orf26 | NSUN5 |
| NMRAL1 | STK25 | NFKB2 | OSBPL1A | VPS37B | RAD23A |
| HS2ST1 | LYAR | PHKA1 | SDC4 | MGST2 | SNTB1 |
| MEN1 | WDR4 | DDX28 | C1orf198 | AKAP9 | COQ9 |
| STYX | PHF5A | PCDH1 | TMSB4X | AP1G2 | MYO1G |
| UCKL1 | APC | TBC1D15 | FASTKD1 | APCDD1L | MARH5 |
| ULK3 | LONP2 | SETD1A | ETFDH | ANKS1A | LRP8 |
| PALD1 | ANAPC5 | CARMIL1 | GATM | PANX1 | NME3 |
| UBA52 | ZNF806 | NCOR2 | DVL2 | CTDP1 | PHKB |
| GINS3 | DNPH1 | CDCA5 | BCKDK | TTF1 | TGFBRAP1 |
| HAUS2 | HMGCR | SNCA | KLHDC4 | TBP | AP1M2 |
| E2F4 | AFAP1L1 | ZMYM6NB | N4BP2 | TRIT1 | CCDC134 |
| ATL1 | INTS6 | CHD8 | SPINT2 | RASA2 | NCK2 |
| MAL2 | ATAD3A | SLC25A32 | LSAMP | ACOT8 | KIFAP3 |
| JARID2 | CLSTN1 | USP36 | PTGIS | PIAS4 | TMEM41B |
| SEC14L1 | TUBGCP4 | GEMIN8 | VWA9 | RPP25L | NRBP2 |
| DOLPP1 | WARS2 | PLEKHA6 | MRGBP | ZCCHC6 | ZFP36L1 |
| SLC4A7 | SCARB1 | ARID1B | PMF1 | XXYLT1 | ANKRD50 |
| MT-CO1 | MET | RBM47 | LIN28B | EXD2 | GORAB |
| GCSH | PLTP | PRKAB1 | CUTC | SDSL | FARS2 |
| LRRC8E | ARHGAP12 | FBXW9 | PMS2 | NAA30 | STRA13 |
| FASTKD5 | ZCCHC10 | TTK | BNC2 | COX16 | BCS1L |
| NDE1 | STX3 | LARP1B | PTCD1 | TPD52 | SMG1 |
| ACBD7 | TRIP12 | PTPMT1 | ASB3 | MTG1 | ANKRD12 |
| STK33 | HEXIM1 | RBM45 | ATG9A | ANKIB1 | B3GALNT2 |
| C12orf43 | SLC25A15 | NDUFAF5 | BAG4 | NOA1 | SFRP2 |
| VPRBP | FOXK1 | GPM6B | POLE | TRADD | AMFR |
| RPS6KA1 | PLA2G4A | SELO | PROM1 | CHTF18 | BOD1 |
| SPC24 | KAT7 | RAB17 | IGFBP6 | PNPLA4 | AGTRAP |
| UBE2Q1 | HIGD2A | RAPH1 | SDF2 | ARHGAP4 | ODR4 |
| MRPS18C | QSOX1 | COX17 | CHUK | RAPGEF2 | GINS1 |
| DFFA | CENPV | PTPN9 | FUT11 | ERMP1 | SOGA1 |
| DHX32 | GEMIN6 | HDHD2 | GLE1 | PTPRZ1 | CREG1 |
| GATC | PDXP | MID1 | WRAP53 | POU2F1 | CA2 |
| APPL1 | TMEM14C | TXNIP | SLC7A3 | FABP6 | ITGA2 |
| CWC22 | MPDZ | PIGG | ACTB | INCENP | CARNMT1 |
| RHBDD2 | MRPL38 | PUM1 | HPDL | NME4 | CDKN2A |
| TRIM27 | ARHGEF10L | BDH1 | CDC26 | CTU1 | ATF7 |
| HMGXB4 | L3MBTL3 | MAP1LC3A | ISLR | URB1 | MRPL21 |
| CAMK1 | RILPL1 | WDR37 | IGF2BP1 | NAPEPLD | DPH6 |
| FCF1 | ANKRD29 | ANAPC13 | CD3EAP | WDR89 | SLC25A17 |
| DNA2 | CENPM | CEP170B | GCA | CSTF2T | NKRF |
| SLC35A2 | PMS1 | SLC5A6 | COQ5 | SPR | RBM15B |
| USP19 | LAMA4 | DNM1L | INTS2 | BCAS3 | KIF22 |
| NHEJ1 | RPP40 | TNC | SPNS1 | RPRD1A | DDB2 |
| IFIT5 | ARMCX1 | FAT1 | DAP | BMPR1A | NPHP3 |
| ARID3A | MRPL13 | ZBED1 | GTF2H1 | PATZ1 | DPH2 |
| C11orf98 | RRP7A | AKAP1 | ANAPC1 | NUDT16 | CD74 |
| DCAKD | ASB6 | DNMBP | UTP11L | TUBG1 | HAUS7 |
| GAA | PDK1 | DOHH | ISYNA1 | BRMS1 | EXOC6 |
| ARAP3 | CHKB | NOL8 | DDX52 | ORC5 | COA7 |
| NAA40 | IQSEC1 | TRIM24 | DNTTIP1 | HEATR6 | SH3BP4 |
| ZMYM3 | MED30 | CLASP2 | PRPF38B | TMEM256 | GTF3C2 |
| MRPL10 | NDUFAF7 | VCPIP1 | HSPB11 | CASP7 | TOR1B |
| ITPR2 | PRPF39 | GCFC2 | KIF21A | DPPA4 | TIMM8B |
| GTF2H4 | MRPL16 | BAZ1A | EXOC6B | MRPL41 | POLR3B |
| USP9Y | SYNE2 | MID1IP1 | MOCS2 | METTL5 | PRUNE |
| UBE2V2 | CDH1 | GJA1 | CHMP6 | RCC1 | RAPGEF6 |
| COMMD9 | HMBS | SQLE | IGFBP2 | DIAPH2 | EPB41 |
| HIST1H1E | MAP3K4 | CDK18 | ARL15 | UQCC1 | HTATIP2 |
| PTDSS2 | TATDN2 | MTA1 | SNX18 | EIF1B | MAEA |
| SCAF1 | UBE2J2 | NUP37 | BAG1 | TSSC4 | RCOR2 |
| FAM213A | MFF | TTLL12 | UBXN6 | EFEMP2 | ZZEF1 |
| NFYB | PDS5B | FXN | AGPAT5 | ARFGEF2 | TCOF1 |
| SCAF11 | RAPGEF1 | PARG | PRIM1 | USF1 | L1TD1 |
| SEPHS1 | BRD8 | POP7 | EXT2 | TSEN34 | CAMKV |
| SLC29A1 | MBD3 | PPIF | MTX3 | COG1 | FASTKD2 |
| ARL14EP | MRPL40 | CD320 | MBD1 | VARS2 | BRD3 |
| MRPS18B | ACY1 | PPIE | RIF1 | VPS8 | POGZ |
| RSL1D1 | PAK1 | STRBP | TERF2 | TOP2A | SLC39A10 |
| QRICH1 | CISD1 | POLB | DHX37 | TRMT5 | TIMMDC1 |
| TRABD | SON | SET | LYST | RNASEH2B | MVK |
| ZC3HC1 | NDUFC1 | HSPA4L | EXOSC1 | TCEANC2 | NASP |
| CYP2S1 | NSMCE3 | HPRT1 | HUS1 | PRRC2A | RDH13 |
| KANK1 | PHF14 | RBM7 | SIRT5 | QPCTL | CROCC |
| LIMK2 | CWF19L1 | KIF1B | VPS39 | CHD7 | YPEL5 |
| SLC7A5 | VPS25 | LRWD1 | FPGS | NT5C3A | NCKIPSD |
| PSIP1 | CELF2 | MDC1 | ANP32A | ACADSB | GPC4 |
| TUBB4A | BOP1 | NT5C | CTSC | ANKLE2 | ORC4 |
| UTP18 | CHST14 | NUS1 | PLK1 | GPKOW | SIKE1 |
| ADAM15 | NUDCD2 | SSU72 | NFYC | LIG1 | MSH2 |
| HNRNPR | MSI2 | STK26 | EBP | ITPK1 | STAU2 |
| URI1 | SLC7A8 | MANBAL | RNGTT | PRIM2 | SEC24B |
| MRPS34 | RMND5A | F11R | SCAF8 | RPAP1 | SPATA5L1 |
| RCC2 | POLRMT | SERF2 | TMEM115 | PARP1 | C2CD5 |
| BEND3 | BRAT1 | TERF2IP | MT-ND2 | FAM136A | NOP2 |
| ARL5B | GFM2 | WDR3 | AARSD1 | PPID | HRSP12 |
| CHD2 | MRPL45 | YTHDF1 | THEMIS | INTS4 | PLEKHA1 |
| CBX3 | SIRT7 | CENPF | CAMSAP2 | MCC | PTPN2 |
| NANOG | SLBP | MCAT | MRPL24 | MZT1 | ANAPC4 |
| HIST1H1A | KPNA2 | MED14 | NDUFB9 | NEFL | DUS3L |
| HSP90AA4P | CMSS1 | ZNF706 | PTRHD1 | PBRM1 | ABI3BP |
| MED10 | PFAS | BRIX1 | QRSL1 | THNSL1 | ADRM1 |
| CECR2 | NCOA5 | ABRACL | WIPF2 | USP28 | GEMIN4 |
| CHD1 | SBNO1 | LSM12 | COG2 | TARS2 | KIF11 |
| CHD1L | MLH1 | MNAT1 | DDX47 | SRPK1 | NACAP1 |
| XPC | NELFCD | MPP6 | HAUS6 | TANC1 | PPAN |
| MRPL33 | PUM2 | MRPL15 | FAM65A | ERI3 | TOM1L2 |
| TIMM13 | SPRYD4 | MICU1 | HMGN5 | XPO4 | WDR43 |
| DDX20 | YTHDC2 | SLC25A22 | CACUL1 | PCF11 | PRC1 |
| DNAAF2 | ACAT1 | RWDD4 | DHPS | PFKM | NUDT16L1 |
| MTMR2 | GPN1 | SMARCA4 | EI24 | SCFD2 | PPP3CB |
| RNASEH2A | GTF2E2 | SMARCD1 | ADCK3 | TRMT1 | RABEP1 |
| CD97 | GLT8D1 | UBR5 | HLTF | TXNRD2 | TDP2 |
| CCNY | NCAPD2 | USP48 | LRCH2 | UBQLN1 | TRIP10 |
| MCM3 | HSPA14 | ZBTB8OS | MAP2K7 | APOBEC3C | TTC27 |
| DYSF | MINA | BAK1 | HERC2 | POLG2 | TRAP1 |
| EXOSC7 | RCL1 | C17orf62 | PUS7 | CASP6 | ISOC1 |
| THYN1 | MYL6 | CBR4 | RFC3 | SRSF10 | LCLAT1 |
| HIBADH | UHRF1 | DHX57 | MCM6 | UBL4A | MRPS17 |
| TFRC | GALK2 | MKI67 | CEBPZ | CHRAC1 | TTC4 |
| METTL3 | GSTZ1 | UBE2O | LRSAM1 | NSA2 | AGPAT4 |
| MRPS5 | MAP3K7 | ZNF330 | MLLT11 | HK2 | BLMH |
| PCCA | LYPLAL1 | CPSF2 | PEX3 | INPP4A | SORD |
| SLC35F2 | MRPL23 | GNL3 | WBP11 | SAP30 | INPPL1 |
| TBC1D9B | MRPS31 | GMPS | IMPDH2 | SSRP1 | LBR |
| TRIM28 | NELFB | LDAH | DDX21 | TWSG1 | RBMX |
| NDUFAF1 | PHF6 | TFB2M | EBNA1BP2 | ZMYM2 | MLYCD |
| UROD | PKP3 | NUBP2 | FANCI | ARIH2 | ZNF22 |
| USP11 | ARFRP1 | PKN1 | FAR1 | MYBBP1A | PDS5A |
| CHMP7 | COASY | SAP18 | GTF3C4 | SMARCAD1 | DNAAF5 |
| CTAGE5 | GART | UBE2I | MRPL27 | ENY2 | PDK3 |
| RUVBL1 | PEAK1 | WDR6 | MYEF2 | PWP2 | RPA2 |
| EXOSC4 | FRA10AC1 | ADAD2 | NARS2 | FAM64A | XRCC4 |
| GTF2E1 | DDX51 | BMS1 | OGFR | MRPL3 | CHAC2 |
| PES1 | IGF2BP3 | LDHB | ORC3 | MSH6 | DPYSL5 |
| HEATR1 | KATNA1 | PTMA | SLC52A2 | NLE1 | MCM7 |
| POLD1 | MCM2 | CXorf56 | SMAD5 | GPATCH4 | STOML2 |
| FLVCR1 | MYH14 | DAXX | ZCCHC8 | TAMM41 | TOMM34 |
| LGALS3BP | PARN | KIF1BP | C5orf22 | TP53RK | NACC1 |
| MRPS30 | TKT | ELAC2 | PRKCI | PDCD11 | DNAJB4 |
| MTMR12 | SUPV3L1 | DARS2 | RAVER1 | SIGMAR1 | DHODH |
| SLC3A2 | BTAF1 | HSDL1 | EIF3C | TBPL1 | NOC2L |
| MRPS28 | CADM1 | MRPL37 | SRI | BZW2 | NDUFC2 |
| PCCB | DNTTIP2 | PCBD2 | TRIM2 | CPSF1 | RABGGTB |
| RFC5 | ECT2 | AGTPBP1 | TRIM22 | ECM29 | PANK4 |
| C11orf73 | MCAM | THUMPD1 | WDR18 | RNPS1 | SCO1 |
| TIMM17B | INTS8 | TUSC3 | DCAF16 | GTF2A1 | SIRT1 |
| UTP6 | MRPL11 | XRN1 | DCTPP1 | HSPBP1 | TUFM |
| WDR92 | PIR | ACAA2 | DNAJC2 | NPM3 | ADNP |
| CERS6 | NUDT12 | APTX | DSG2 | NTHL1 | BOLA3 |
| DDX24 | NUP35 | ATL2 | NOL11 | DDX31 | ATPAF1 |
| GCDH | RCHY1 | C12orf10 | HIP1R | PRPS2 | MCM5 |
| WDR75 | RHOT1 | KIAA1211 | DDX54 | RSPRY1 | CDC123 |
| NOP16 | TACO1 | GLMN | HOOK1 | WNK1 | NUP155 |
| POLR1A | TBL3 | GNAI1 | KIAA2013 | C7orf50 | GUSB |
| GUF1 | TIMM17A | GRWD1 | LBH | CCNK | ILKAP |
| SMYD5 | AGL | POR | LIG3 | CMTR1 | LRBA |
| WDR5 | TOMM5 | ARL8A | PCK2 | PDCD4 | NAT10 |
| ACO1 | TSC2 | GNL3L | MTFP1 | ABT1 | KEAP1 |
| ANKRD28 | UBTF | STK3 | SCAP | PPAT | PSAT1 |
| APOA1BP | WDR54 | SYT1 | SCRIB | PTBP3 | RNASEH2C |
| APOO | ASF1A | GSPT2 | SDHB | SUPT16H | DBR1 |
| PSME3 | PPWD1 | UBQLN4 | CHAF1A | TRMT10C | SACS |
| BYSL | CDH13 | USP24 | ARID1A | GJB2 | TEX10 |
| UBA2 | CLUH | ARL2 | AS3MT | ABCC1 | MRPL57 |
| DDX56 | EIF2D | ATP1B3 | DCAF8 | AGK | AIF1L |
| RBM42 | FEN1 | CCDC12 | ELOVL6 | EFNB1 | NCAPG2 |
| SARS2 | OSBPL2 | CDCA8 | GNA13 | ATF7IP | CCDC50 |
| ADI1 | HAUS8 | C1orf131 | GOLM1 | DEK | DTD1 |
| MCL1 | INTS1 | AHCY | GYS1 | PAICS | DTWD1 |
| CCDC59 | MAK16 | RUVBL2 | ISY1 | ECT2L | GTPBP10 |
| ZNF593 | RBM26 | FDXR | MRI1 | HS1BP3 | LSM6 |
| DNAJC8 | SALL4 | AATF | LETM1 | LAS1L | MRPS11 |
| SMARCA5 | TMPO | LTA4H | MYCBP | MRPL19 | NEPRO |
| PCBP2 | WBSCR22 | CCNH | DLGAP5 | NDUFS7 | NOP58 |
| HDAC2 | WDR48 | GLTSCR2 | PELP1 | HARS2 | NT5DC1 |
| HIST1H1B | TOX4 | TPI1 | LUC7L | ATP11C | NXF1 |
| HNRNPC | VRK1 | KDM2A | COMMD8 | CACNA2D1 | RAD21 |
| HNRNPU | WIPI1 | USP39 | SSB | CDCA7L | SNF8 |
| LARS | ASH2L | VPS36 | ZNF346 | CRNKL1 | TELO2 |
| LRRC57 | AASDHPPT | CNPY3 | GLUL | CWC27 | TNPO3 |
| CHORDC1 | CKAP2 | CXADR | ILF2 | PEG10 | TTI2 |
| MANBA | DCAF13 | PLS1 | LVRN | C1QBP | UBE2A |
| MEMO1 | EIF4A3 | EXTL2 | MED24 | GLYR1 | UBXN1 |
| MRPS18A | EIF5B | NIFK | POLR2H | HMOX2 | ABCB6 |
| NDUFB4 | FNBP1L | NOL10 | KIF5C | EXOSC9 | ATP2B1 |
| TOMM40 | RBM28 | GSTP1 | TATDN1 | FTSJ3 | DAGLB |
| PLCG1 | IFI16 | HSPA4 | TMEM192 | MPI | SMPD4 |
| POLE4 | KDM1A | NUP188 | TSFM | DLAT | FAM210A |
| POLR2D | NOL6 | PRPF40A | UBAP2 | MSTO1 | GTF2I |
| SHPK | NUP133 | RBM12B | DAB2IP | SAFB | LARP1 |
| SPCS1 | PDHA1 | STX18 | PPFIA1 | NUP50 | METTL13 |
| SAAL1 | QTRTD1 | SUPT6H | ADSL | QSER1 | POLR3C |
| TRMT1L | ASUN | BMP1 | AFG3L2 | GEMIN5 | NEU1 |
| PEX6 | HDAC3 | NDC80 | MRRF | HMGN1 | TIMM44 |
| REEP6 | OTX2 | LPCAT1 | MTPAP | SNU13 | UMPS |
| TRIAP1 | TUT1 | GRSF1 | NAA20 | ACSS3 | NCK1 |
| ERBB2 | CCDC28B | XRN2 | NDUFAF4 | MIF | PPP2R5A |
| SGSH | CRADD | MT-ND4 | GATAD2A | MRPL9 | RAD50 |
| OSGEPL1 | ADGRL2 | MTUS2 | NRBF2 | FAM192A | DNPEP |
| THAP11 | HEATR5B | RABGEF1 | POP1 | HEATR3 | SRRM2 |
| CACTIN | PRKD1 | MRPL50 | PRMT1 | NIPBL | STK4 |
| SLC25A35 | ECE2 | RPL13A | SDCBP | NTMT1 | TBRG4 |
| ZFAND6 | DSEL | SDAD1 | RPL21 | PDCD5 | PPIG |
| RALGAPB | MYO5C | TRMT6 | RBM39 | GULP1 | DCP1A |
| IGSF1 | POLG | UBE3A | SLC30A1 | RFC4 | TUBAL3 |
| MGRN1 | TPK1 | KCTD10 | SMAP | ACIN1 | UBXN7 |
| TMEM41A | DNAL1 | F8A1,F8A2,F8A3 | TKFC | BSG | ARHGEF40 |
| FBP1 | FBXL6 | DFFB | TRIM33 | EHBP1 | ATP5S |
| CDC20 | PLEKHA7 | WDR73 | CD70 | EMC3 | SLC9A3R1 |
| COBLL1 | TRIM9 | SP1 | YARS2 | RBM19 | CKMT1A,CKMT1B |
| HSP90AB3P | MRPL35 | CCNA2 | HDDC2 | KDM3B | PPA1 |
| SMARCAL1 | MALSU1 | AURKB | PPM1G | EARS2 | HSP90AA1 |
| SH3GL3 | MPHOSPH6 | NACC2 | HMGB2 | GTPBP4 | ABCB10 |
| CYP2U1 | BSDC1 | TLK1 | LEO1 | MFAP1 | GIT1 |
| FLCN | TYRO3 | SH3PXD2A | EMC4 | CPS1 | INTS9 |
| IRS2 | SIRT3 | FUT8 | CDK2 | TNFAIP6 | SDHAF4 |
| KITLG | ALDH3A1 | GPR180 | CFAP36 | ANK3 | CBX2 |
| RBBP9 | EML2 | POLR3GL | FN3K | VWA5A | RAVER2 |
| ATXN7L3B | TIMM21 | SLC2A3 | CA14 | CRLF3 | SYT6 |
| TMEM161A | MTM1 | METTL15 | NKAP | CDS2 | MRS2 |
| MARS2 | ERCC2 | TDP1 | MFAP4 | ANAPC16 | CARS2 |
| NOLC1 | IGHMBP2 | MRPL34 | FECH | PARP2 | ING1 |
| ADNP2 | STEAP3 | AK6 | PDZD8 | EPB41L5 | PEX16 |
| ZER1 | CKS1B | GGPS1 | DBNDD1 | MIEF1 | FUCA1 |
| ADSSL1 | POTEJ | TMEM209 | CCNL2 | TOP3A | ULK1 |
| MGA | FAM162A | AMMECR1 | ISG20L2 | CEP78 | NOM1 |
| PAPD4 | PROCR | IFRD2 | LRRC41 | UBR3 | PHF3 |
| RIN1 | SPPL2B | ARAF | DNM2 | HPS5 | PSEN1 |
| PARD3 | ARHGEF16 | RHPN2 | PRPF18 | SEMA4C | RPUSD3 |
| NYNRIN | ARHGEF7 | VRTN | PHF10 | DMD | RPL26L1 |
| RANBP6 | CNOT4 | TSPYL5 | CDC25C | REEP4 | FADD |
| INPP5F | ZBTB7A | GPN3 | RBPMS2 | BRAF | ORC6 |
| CACNA2D2 | AP1B1 | NCAPD3 | RRP8 | MASTL | POLR2M |
| CASC3 | NCL | C1orf174 | LRRC14 | SLC27A3 | ACSF3 |
| DHRS11 | RBM23 | WDR55 | CAMK4 | NDRG3 | ALS2 |
| NOVA1 | SOX3 | CLCN7 | EHMT1 | C7orf26 | NSUN5 |
| NMRAL1 | STK25 | NFKB2 | OSBPL1A | VPS37B | RAD23A |
| HS2ST1 | LYAR | PHKA1 | SDC4 | MGST2 | SNTB1 |
| MEN1 | WDR4 | DDX28 | C1orf198 | AKAP9 | COQ9 |
| STYX | PHF5A | PCDH1 | TMSB4X | AP1G2 | MYO1G |
| UCKL1 | APC | TBC1D15 | FASTKD1 | APCDD1L | MARH5 |
| ULK3 | LONP2 | SETD1A | ETFDH | ANKS1A | LRP8 |
| PALD1 | ANAPC5 | CARMIL1 | GATM | PANX1 | NME3 |
| UBA52 | ZNF806 | NCOR2 | DVL2 | CTDP1 | PHKB |
| GINS3 | DNPH1 | CDCA5 | BCKDK | TTF1 | TGFBRAP1 |
| HAUS2 | HMGCR | SNCA | KLHDC4 | TBP | AP1M2 |
| E2F4 | AFAP1L1 | ZMYM6NB | N4BP2 | TRIT1 | CCDC134 |
| ATL1 | INTS6 | CHD8 | SPINT2 | RASA2 | NCK2 |
| MAL2 | ATAD3A | SLC25A32 | LSAMP | ACOT8 | KIFAP3 |
| JARID2 | CLSTN1 | USP36 | PTGIS | PIAS4 | TMEM41B |
| SEC14L1 | TUBGCP4 | GEMIN8 | VWA9 | RPP25L | NRBP2 |
| DOLPP1 | WARS2 | PLEKHA6 | MRGBP | ZCCHC6 | ZFP36L1 |
| SLC4A7 | SCARB1 | ARID1B | PMF1 | XXYLT1 | ANKRD50 |
| MT-CO1 | MET | RBM47 | LIN28B | EXD2 | GORAB |
| GCSH | PLTP | PRKAB1 | CUTC | SDSL | FARS2 |
| LRRC8E | ARHGAP12 | FBXW9 | PMS2 | NAA30 | STRA13 |
| FASTKD5 | ZCCHC10 | TTK | BNC2 | COX16 | BCS1L |
| NDE1 | STX3 | LARP1B | PTCD1 | TPD52 | SMG1 |
| ACBD7 | TRIP12 | PTPMT1 | ASB3 | MTG1 | ANKRD12 |
| STK33 | HEXIM1 | RBM45 | ATG9A | ANKIB1 | B3GALNT2 |
| C12orf43 | SLC25A15 | NDUFAF5 | BAG4 | NOA1 | SFRP2 |
| VPRBP | FOXK1 | GPM6B | POLE | TRADD | AMFR |
| RPS6KA1 | PLA2G4A | SELO | PROM1 | CHTF18 | BOD1 |
| SPC24 | KAT7 | RAB17 | IGFBP6 | PNPLA4 | AGTRAP |
| UBE2Q1 | HIGD2A | RAPH1 | SDF2 | ARHGAP4 | ODR4 |
| MRPS18C | QSOX1 | COX17 | CHUK | RAPGEF2 | GINS1 |
| DFFA | CENPV | PTPN9 | FUT11 | ERMP1 | SOGA1 |
| DHX32 | GEMIN6 | HDHD2 | GLE1 | PTPRZ1 | CREG1 |
| GATC | PDXP | MID1 | WRAP53 | POU2F1 | CA2 |
| APPL1 | TMEM14C | TXNIP | SLC7A3 | FABP6 | ITGA2 |
| CWC22 | MPDZ | PIGG | ACTB | INCENP | CARNMT1 |
| RHBDD2 | MRPL38 | PUM1 | HPDL | NME4 | CDKN2A |
| TRIM27 | ARHGEF10L | BDH1 | CDC26 | CTU1 | ATF7 |
| HMGXB4 | L3MBTL3 | MAP1LC3A | ISLR | URB1 | MRPL21 |
| CAMK1 | RILPL1 | WDR37 | IGF2BP1 | NAPEPLD | DPH6 |
| FCF1 | ANKRD29 | ANAPC13 | CD3EAP | WDR89 | SLC25A17 |
| DNA2 | CENPM | CEP170B | GCA | CSTF2T | NKRF |
| SLC35A2 | PMS1 | SLC5A6 | COQ5 | SPR | RBM15B |
| USP19 | LAMA4 | DNM1L | INTS2 | BCAS3 | KIF22 |
| NHEJ1 | RPP40 | TNC | SPNS1 | RPRD1A | DDB2 |
| IFIT5 | ARMCX1 | FAT1 | DAP | BMPR1A | NPHP3 |
| ARID3A | MRPL13 | ZBED1 | GTF2H1 | PATZ1 | DPH2 |
| C11orf98 | RRP7A | AKAP1 | ANAPC1 | NUDT16 | CD74 |
| DCAKD | ASB6 | DNMBP | UTP11L | TUBG1 | HAUS7 |
| GAA | PDK1 | DOHH | ISYNA1 | BRMS1 | EXOC6 |
| ARAP3 | CHKB | NOL8 | DDX52 | ORC5 | COA7 |
| NAA40 | IQSEC1 | TRIM24 | DNTTIP1 | HEATR6 | SH3BP4 |
| ZMYM3 | MED30 | CLASP2 | PRPF38B | TMEM256 | GTF3C2 |
| MRPL10 | NDUFAF7 | VCPIP1 | HSPB11 | CASP7 | TOR1B |
| ITPR2 | PRPF39 | GCFC2 | KIF21A | DPPA4 | TIMM8B |
| GTF2H4 | MRPL16 | BAZ1A | EXOC6B | MRPL41 | POLR3B |
| USP9Y | SYNE2 | MID1IP1 | MOCS2 | METTL5 | PRUNE |
| UBE2V2 | CDH1 | GJA1 | CHMP6 | RCC1 | RAPGEF6 |
| COMMD9 | HMBS | SQLE | IGFBP2 | DIAPH2 | EPB41 |
| HIST1H1E | MAP3K4 | CDK18 | ARL15 | UQCC1 | HTATIP2 |
| PTDSS2 | TATDN2 | MTA1 | SNX18 | EIF1B | MAEA |
| SCAF1 | UBE2J2 | NUP37 | BAG1 | TSSC4 | RCOR2 |
| FAM213A | MFF | TTLL12 | UBXN6 | EFEMP2 | ZZEF1 |
| NFYB | PDS5B | FXN | AGPAT5 | ARFGEF2 | TCOF1 |
| SCAF11 | RAPGEF1 | PARG | PRIM1 | USF1 | L1TD1 |
| SEPHS1 | BRD8 | POP7 | EXT2 | TSEN34 | CAMKV |
| SLC29A1 | MBD3 | PPIF | MTX3 | COG1 | FASTKD2 |
| ARL14EP | MRPL40 | CD320 | MBD1 | VARS2 | BRD3 |
| MRPS18B | ACY1 | PPIE | RIF1 | VPS8 | POGZ |
| RSL1D1 | PAK1 | STRBP | TERF2 | TOP2A | SLC39A10 |
| QRICH1 | CISD1 | POLB | DHX37 | TRMT5 | TIMMDC1 |
| TRABD | SON | SET | LYST | RNASEH2B | MVK |
| ZC3HC1 | NDUFC1 | HSPA4L | EXOSC1 | TCEANC2 | NASP |
| CYP2S1 | NSMCE3 | HPRT1 | HUS1 | PRRC2A | RDH13 |
| KANK1 | PHF14 | RBM7 | SIRT5 | QPCTL | CROCC |
| LIMK2 | CWF19L1 | KIF1B | VPS39 | CHD7 | YPEL5 |
| SLC7A5 | VPS25 | LRWD1 | FPGS | NT5C3A | NCKIPSD |
| PSIP1 | CELF2 | MDC1 | ANP32A | ACADSB | GPC4 |
| TUBB4A | BOP1 | NT5C | CTSC | ANKLE2 | ORC4 |
| UTP18 | CHST14 | NUS1 | PLK1 | GPKOW | SIKE1 |
| ADAM15 | NUDCD2 | SSU72 | NFYC | LIG1 | MSH2 |
| HNRNPR | MSI2 | STK26 | EBP | ITPK1 | STAU2 |
| URI1 | SLC7A8 | MANBAL | RNGTT | PRIM2 | SEC24B |
| MRPS34 | RMND5A | F11R | SCAF8 | RPAP1 | SPATA5L1 |
| RCC2 | POLRMT | SERF2 | TMEM115 | PARP1 | C2CD5 |
| BEND3 | BRAT1 | TERF2IP | MT-ND2 | FAM136A | NOP2 |
| ARL5B | GFM2 | WDR3 | AARSD1 | PPID | HRSP12 |
| CHD2 | MRPL45 | YTHDF1 | THEMIS | INTS4 | PLEKHA1 |
| CBX3 | SIRT7 | CENPF | CAMSAP2 | MCC | PTPN2 |
| NANOG | SLBP | MCAT | MRPL24 | MZT1 | ANAPC4 |
| HIST1H1A | KPNA2 | MED14 | NDUFB9 | NEFL | DUS3L |
| HSP90AA4P | CMSS1 | ZNF706 | PTRHD1 | PBRM1 | ABI3BP |
| MED10 | PFAS | BRIX1 | QRSL1 | THNSL1 | ADRM1 |
| CECR2 | NCOA5 | ABRACL | WIPF2 | USP28 | GEMIN4 |
| CHD1 | SBNO1 | LSM12 | COG2 | TARS2 | KIF11 |
| CHD1L | MLH1 | MNAT1 | DDX47 | SRPK1 | NACAP1 |
| XPC | NELFCD | MPP6 | HAUS6 | TANC1 | PPAN |
| MRPL33 | PUM2 | MRPL15 | FAM65A | ERI3 | TOM1L2 |
| TIMM13 | SPRYD4 | MICU1 | HMGN5 | XPO4 | WDR43 |
| DDX20 | YTHDC2 | SLC25A22 | CACUL1 | PCF11 | PRC1 |
| DNAAF2 | ACAT1 | RWDD4 | DHPS | PFKM | NUDT16L1 |
| MTMR2 | GPN1 | SMARCA4 | EI24 | SCFD2 | PPP3CB |
| RNASEH2A | GTF2E2 | SMARCD1 | ADCK3 | TRMT1 | RABEP1 |
| CD97 | GLT8D1 | UBR5 | HLTF | TXNRD2 | TDP2 |
| CCNY | NCAPD2 | USP48 | LRCH2 | UBQLN1 | TRIP10 |
| MCM3 | HSPA14 | ZBTB8OS | MAP2K7 | APOBEC3C | TTC27 |
| DYSF | MINA | BAK1 | HERC2 | POLG2 | TRAP1 |
| EXOSC7 | RCL1 | C17orf62 | PUS7 | CASP6 | ISOC1 |
| THYN1 | MYL6 | CBR4 | RFC3 | SRSF10 | LCLAT1 |
| HIBADH | UHRF1 | DHX57 | MCM6 | UBL4A | MRPS17 |
| TFRC | GALK2 | MKI67 | CEBPZ | CHRAC1 | TTC4 |
| METTL3 | GSTZ1 | UBE2O | LRSAM1 | NSA2 | AGPAT4 |
| MRPS5 | MAP3K7 | ZNF330 | MLLT11 | HK2 | BLMH |
| PCCA | LYPLAL1 | CPSF2 | PEX3 | INPP4A | SORD |
| SLC35F2 | MRPL23 | GNL3 | WBP11 | SAP30 | INPPL1 |
| TBC1D9B | MRPS31 | GMPS | IMPDH2 | SSRP1 | LBR |
| TRIM28 | NELFB | LDAH | DDX21 | TWSG1 | RBMX |
| NDUFAF1 | PHF6 | TFB2M | EBNA1BP2 | ZMYM2 | MLYCD |
| UROD | PKP3 | NUBP2 | FANCI | ARIH2 | ZNF22 |
| USP11 | ARFRP1 | PKN1 | FAR1 | MYBBP1A | PDS5A |
| CHMP7 | COASY | SAP18 | GTF3C4 | SMARCAD1 | DNAAF5 |
| CTAGE5 | GART | UBE2I | MRPL27 | ENY2 | PDK3 |
| RUVBL1 | PEAK1 | WDR6 | MYEF2 | PWP2 | RPA2 |
| EXOSC4 | FRA10AC1 | ADAD2 | NARS2 | FAM64A | XRCC4 |
| GTF2E1 | DDX51 | BMS1 | OGFR | MRPL3 | CHAC2 |
| PES1 | IGF2BP3 | LDHB | ORC3 | MSH6 | DPYSL5 |
| HEATR1 | KATNA1 | PTMA | SLC52A2 | NLE1 | MCM7 |
| POLD1 | MCM2 | CXorf56 | SMAD5 | GPATCH4 | STOML2 |
| FLVCR1 | MYH14 | DAXX | ZCCHC8 | TAMM41 | TOMM34 |
| LGALS3BP | PARN | KIF1BP | C5orf22 | TP53RK | NACC1 |
| MRPS30 | TKT | ELAC2 | PRKCI | PDCD11 | DNAJB4 |
| MTMR12 | SUPV3L1 | DARS2 | RAVER1 | SIGMAR1 | DHODH |
| SLC3A2 | BTAF1 | HSDL1 | EIF3C | TBPL1 | NOC2L |
| MRPS28 | CADM1 | MRPL37 | SRI | BZW2 | NDUFC2 |
| PCCB | DNTTIP2 | PCBD2 | TRIM2 | CPSF1 | RABGGTB |
| RFC5 | ECT2 | AGTPBP1 | TRIM22 | ECM29 | PANK4 |
| C11orf73 | MCAM | THUMPD1 | WDR18 | RNPS1 | SCO1 |
| TIMM17B | INTS8 | TUSC3 | DCAF16 | GTF2A1 | SIRT1 |
| UTP6 | MRPL11 | XRN1 | DCTPP1 | HSPBP1 | TUFM |
| WDR92 | PIR | ACAA2 | DNAJC2 | NPM3 | ADNP |
| CERS6 | NUDT12 | APTX | DSG2 | NTHL1 | BOLA3 |
| DDX24 | NUP35 | ATL2 | NOL11 | DDX31 | ATPAF1 |
| GCDH | RCHY1 | C12orf10 | HIP1R | PRPS2 | MCM5 |
| WDR75 | RHOT1 | KIAA1211 | DDX54 | RSPRY1 | CDC123 |
| NOP16 | TACO1 | GLMN | HOOK1 | WNK1 | NUP155 |
| POLR1A | TBL3 | GNAI1 | KIAA2013 | C7orf50 | GUSB |
| GUF1 | TIMM17A | GRWD1 | LBH | CCNK | ILKAP |
| SMYD5 | AGL | POR | LIG3 | CMTR1 | LRBA |
| WDR5 | TOMM5 | ARL8A | PCK2 | PDCD4 | NAT10 |
| ACO1 | TSC2 | GNL3L | MTFP1 | ABT1 | KEAP1 |
| ANKRD28 | UBTF | STK3 | SCAP | PPAT | PSAT1 |
| APOA1BP | WDR54 | SYT1 | SCRIB | PTBP3 | RNASEH2C |
| APOO | ASF1A | GSPT2 | SDHB | SUPT16H | DBR1 |
| PSME3 | PPWD1 | UBQLN4 | CHAF1A | TRMT10C | SACS |
| BYSL | CDH13 | USP24 | ARID1A | GJB2 | TEX10 |
| UBA2 | CLUH | ARL2 | AS3MT | ABCC1 | MRPL57 |
| DDX56 | EIF2D | ATP1B3 | DCAF8 | AGK | AIF1L |
| RBM42 | FEN1 | CCDC12 | ELOVL6 | EFNB1 | NCAPG2 |
| SARS2 | OSBPL2 | CDCA8 | GNA13 | ATF7IP | CCDC50 |
| ADI1 | HAUS8 | C1orf131 | GOLM1 | DEK | DTD1 |
| MCL1 | INTS1 | AHCY | GYS1 | PAICS | DTWD1 |
| CCDC59 | MAK16 | RUVBL2 | ISY1 | ECT2L | GTPBP10 |
| ZNF593 | RBM26 | FDXR | MRI1 | HS1BP3 | LSM6 |
| DNAJC8 | SALL4 | AATF | LETM1 | LAS1L | MRPS11 |
| SMARCA5 | TMPO | LTA4H | MYCBP | MRPL19 | NEPRO |
| PCBP2 | WBSCR22 | CCNH | DLGAP5 | NDUFS7 | NOP58 |
| HDAC2 | WDR48 | GLTSCR2 | PELP1 | HARS2 | NT5DC1 |
| HIST1H1B | TOX4 | TPI1 | LUC7L | ATP11C | NXF1 |
| HNRNPC | VRK1 | KDM2A | COMMD8 | CACNA2D1 | RAD21 |
| HNRNPU | WIPI1 | USP39 | SSB | CDCA7L | SNF8 |
| LARS | ASH2L | VPS36 | ZNF346 | CRNKL1 | TELO2 |
| LRRC57 | AASDHPPT | CNPY3 | GLUL | CWC27 | TNPO3 |
| CHORDC1 | CKAP2 | CXADR | ILF2 | PEG10 | TTI2 |
| MANBA | DCAF13 | PLS1 | LVRN | C1QBP | UBE2A |
| MEMO1 | EIF4A3 | EXTL2 | MED24 | GLYR1 | UBXN1 |
| MRPS18A | EIF5B | NIFK | POLR2H | HMOX2 | ABCB6 |
| NDUFB4 | FNBP1L | NOL10 | KIF5C | EXOSC9 | ATP2B1 |
| TOMM40 | RBM28 | GSTP1 | TATDN1 | FTSJ3 | DAGLB |
| PLCG1 | IFI16 | HSPA4 | TMEM192 | MPI | SMPD4 |
| POLE4 | KDM1A | NUP188 | TSFM | DLAT | FAM210A |
| POLR2D | NOL6 | PRPF40A | UBAP2 | MSTO1 | GTF2I |
| SHPK | NUP133 | RBM12B | DAB2IP | SAFB | LARP1 |
| SPCS1 | PDHA1 | STX18 | PPFIA1 | NUP50 | METTL13 |
| SAAL1 | QTRTD1 | SUPT6H | ADSL | QSER1 | POLR3C |
| TRMT1L | ASUN | BMP1 | AFG3L2 | GEMIN5 | NEU1 |
| PEX6 | HDAC3 | NDC80 | MRRF | HMGN1 | TIMM44 |
| REEP6 | OTX2 | LPCAT1 | MTPAP | SNU13 | UMPS |
| TRIAP1 | TUT1 | GRSF1 | NAA20 | ACSS3 | NCK1 |
| ERBB2 | CCDC28B | XRN2 | NDUFAF4 | MIF | PPP2R5A |
| SGSH | CRADD | MT-ND4 | GATAD2A | MRPL9 | RAD50 |
| OSGEPL1 | ADGRL2 | MTUS2 | NRBF2 | FAM192A | DNPEP |
| THAP11 | HEATR5B | RABGEF1 | POP1 | HEATR3 | SRRM2 |
| CACTIN | PRKD1 | MRPL50 | PRMT1 | NIPBL | STK4 |
| SLC25A35 | ECE2 | RPL13A | SDCBP | NTMT1 | TBRG4 |
| ZFAND6 | DSEL | SDAD1 | RPL21 | PDCD5 | PPIG |
| RALGAPB | MYO5C | TRMT6 | RBM39 | GULP1 | DCP1A |
| IGSF1 | POLG | UBE3A | SLC30A1 | RFC4 | TUBAL3 |
| MGRN1 | TPK1 | KCTD10 | SMAP | ACIN1 | UBXN7 |
| TMEM41A | DNAL1 | F8A1,F8A2,F8A3 | TKFC | BSG | ARHGEF40 |
| FBP1 | FBXL6 | DFFB | TRIM33 | EHBP1 | ATP5S |
| CDC20 | PLEKHA7 | WDR73 | CD70 | EMC3 | SLC9A3R1 |
| COBLL1 | TRIM9 | SP1 | YARS2 | RBM19 | CKMT1A,CKMT1B |
| HSP90AB3P | MRPL35 | CCNA2 | HDDC2 | KDM3B | PPA1 |
| SMARCAL1 | MALSU1 | AURKB | PPM1G | EARS2 | HSP90AA1 |
| SH3GL3 | MPHOSPH6 | NACC2 | HMGB2 | GTPBP4 | ABCB10 |
| CYP2U1 | BSDC1 | TLK1 | LEO1 | MFAP1 | GIT1 |
| FLCN | TYRO3 | SH3PXD2A | EMC4 | CPS1 | INTS9 |
| IRS2 | SIRT3 | FUT8 | CDK2 | TNFAIP6 | SDHAF4 |
| KITLG | ALDH3A1 | GPR180 | CFAP36 | ANK3 | CBX2 |
| RBBP9 | EML2 | POLR3GL | FN3K | VWA5A | RAVER2 |
| (ii) Proteins enriched more than two-fold in c-MYC-WT compared with MYCL-WT (EpiP) | |||||
|---|---|---|---|---|---|
| FIGNL2 | MCEE | NDUFB7 | BCCIP | CCDC86 | HSPA4L |
| URB1 | INTS14 | MRPS10 | PDHX | SNCA | RPL26L1 |
| NBN | DNAJC2 | NDUFAF2 | WDR36 | UBE2G1 | INTS3 |
| NDUFB1 | EIF3C | WARS2 | SUPV3L1 | TOP2A | ANKZF1 |
| PCCA | AKAP9 | NOP16 | EHMT2 | MRPL3 | KAT7 |
| POLR3D | MAPKAP1 | PAIP1 | GK | INTS13 | MT-ATP6 |
| NF1 | NABP2 | OSBPL11 | IMPDH2 | DIEXF | WDR73 |
| BRD2 | MCM7 | SFXN4 | HSPD1 | REXO4 | GEMIN4 |
| NCAPD3 | NDFIP1 | BOP1 | PM20D2 | TRMT5 | STEAP3 |
| SSR2 | MTA3 | TOMM40 | PDS5A | SLC25A17 | RIDA |
| GTF2A2 | DCUN1D5 | ORC5 | CDKN2AIPNL | SET | TFAM |
| CORO7 | THTPA | POLR1B | HSPE1 | APOO | NDUFS7 |
| UBE2G2 | WRAP53 | HARS2 | POLRMT | IRF9 | RBM19 |
| PPP4R3B | DPCD | FBXO22 | CLUH | TSR1 | ZNF740 |
| ATP7A | HIGD2A | TIMM17A | COA7 | ALKBH5 | TTI1 |
| ATR | ITPA | PABPN1 | TYMS | RARS2 | PHC2 |
| MBTPS1 | FAM234A | LPCAT3 | BMS1 | INTS11 | UBE2S |
| VAMP3 | TTC12 | TNPO2 | NOC3L | TBL3 | POLR1A |
| PFKFB3 | CARS2 | FBL | LSAMP | ABHD11 | ORC2 |
| SH3PXD2A | INCENP | SMN1,SMN2 | GNL3 | MRPS15 | MRPL17 |
| ZNF318 | ITM2C | NIP7 | SYF2 | UCK2 | MARS2 |
| CWF19L1 | INTS9 | CDK1 | STK26 | IRF2BP2 | PTCD1 |
| RBX1 | POLR3B | SLC4A7 | DNPH1 | DIMT1 | DUS3L |
| ULK3 | IFT57 | NDUFAF4 | NGDN | PCBP2 | CEPT1 |
| TTC33 | ARMCX1 | HDDC3 | PPIF | MDC1 | PES1 |
| CWC27 | TRAP1 | BRIX1 | TOMM6 | NCAPG | PWP2 |
| NOL11 | DDX41 | GCA | DDX20 | HEATR1 | NT5DC2 |
| KDM3B | TASOR | NCL | MGST1 | GTF2H4 | SSNA1 |
| ZC3HC1 | PALD1 | EEF1E1 | TRMT10C | NUDT3 | COIL |
| VRK2 | SYNPO2 | PSMF1 | PTBP3 | TGS1 | NOL10 |
| DDX60 | HIGD1A | RAB11FIP5 | C1QBP | BCS1L | POLD3 |
| PHACTR4 | SIK3 | TRIM65 | DNMT1 | LYAR | YY1 |
| ASPM | CABIN1 | WDR43 | POLD2 | WDR3 | DCAF1 |
| GPD1L | MAP3K4 | MYC | FAM162A | DDX18 | WDHD1 |
| GTF3C2 | MYBBP1A | URB2 | HMGN5 | BAZ1A | MDP1 |
| STAG1 | DDX21 | VRK1 | GUCY1B2 | SLC1A3 | MTMR6 |
| COX6A1 | TMEM33 | UBE2D3 | RFC5 | RRP1 | NEDD4 |
| SAAL1 | NPM3 | TEX10 | CDK2AP1 | POLR2F | RSL1D1 |
| EDC3 | PLA2G4A | HMGA1 | DDX24 | TRRAP | SELENOO |
| DTD2 | MED23 | PBX1 | UTP4 | H1-4 | FANCI |
| SLC35E1 | PEG10 | GRPEL1 | DPH2 | DNAJA3 | HAUS1 |
| CCDC115 | NOLC1 | GNL2 | POLD1 | MRPS2 | ZNF565 |
| PVR | AKAP1 | PRRX1 | NDUFAF3 | PARP12 | STRIP1 |
| ZCCHC3 | NELFCD | PODXL2 | PRR35 | KDM1B | BMI1 |
| TRAPPC8 | SPNS1 | BLOC1S4 | UMODL1 | KIF21B | C8orf33 |
| NFIX | AFP | TTN | RAVER2 | NFATC2IP | CHD1 |
| UBE2D1 | DHX38 | CDK5RAP1 | IDUA | IRAK1 | ORMDL3 |
| GPAA1 | B3GALT6 | XPC | LIN7C | VWA1 | MET |
| METTL1 | COA4 | CTIF | SHPK | PNKP | |
| (iii) Proteins enriched more than two-fold in c-MYC-WT compared with c-MYC-ΔMB0 (EpiP) | |||||
|---|---|---|---|---|---|
| FAM83G | IFT20 | DOP1B | NOC3L | POLR2F | EXOC8 |
| STK25 | ASPM | WIPI2 | LSAMP | KHNYN | S100A3 |
| BTAF1 | GPD1L | OARD1 | ARF1 | HACD2 | VWA1 |
| URB1 | STAG2 | SLC25A15 | SYF2 | RIDA | METTL1 |
| PCDHGA12 | CCNYL1 | IKBKG | GXYLT1 | CEP250 | SMARCA4 |
| TGFB1 | NECAP1 | MAP3K4 | NLE1 | RBM19 | PRIM2 |
| SERPINE2 | PPHLN1 | UTP3 | PTBP3 | LMF2 | SHPK |
| SP1 | STAG1 | CD320 | YTHDF2 | ORC2 | F8A1,F8A2,F8A3 |
| GLUL | SREK1 | ARMC9 | C7orf50 | MRPL17 | BMI1 |
| PHKG2 | COX6A1 | RPL36A | DNMT1 | MARS2 | C8orf33 |
| NF1 | BRI3BP | LAS1L | FAM162A | PTCD1 | CCDC93 |
| BRD2 | LPIN2 | PLA2G4A | HMGN5 | CEPT1 | MET |
| ATP6V0C | ZNF622 | PEG10 | CDK2AP1 | LIMD2 | COA4 |
| NCAPD3 | SNX21 | CCDC58 | NUP50 | ORC4 | TTC5 |
| SSR2 | NUDT16 | LYRM7 | SLC16A1 | LAGE3 | CCDC63 |
| PRIM1 | SAAL1 | WARS2 | ERCC4 | RMC1 | PODXL2 |
| GTF2A2 | DTD2 | ZNF24 | UTP4 | NOL10 | BLOC1S4 |
| EPHB3 | WASF2 | NAA16 | BUD23 | POLD3 | CDK5RAP1 |
| UBE2G2 | CCDC115 | BOP1 | SELENBP1 | H2AC21 | SPATA5L1 |
| PLCB3 | HAPLN3 | TNFRSF10B | SNCA | CNBP | XPC |
| ATP7A | DNAJC2 | ORC5 | VPS33A | CAMLG | MPC1 |
| PTK2 | AKAP9 | HARS2 | CTSC | DOCK1 | MIPEP |
| HSPA14 | THTPA | TIMM17A | INTS13 | SPR | PVR |
| ATR | CEP41 | PABPN1 | REXO4 | CSNK2A1 | AKAP1 |
| VAMP3 | XPO4 | NOLC1 | CCDC51 | SRC | |
| PFKFB3 | CSTF2T | SMN1,SMN2 | APOO | CLPB | AFP |
| DOCK11 | QRSL1 | WRNIP1 | MSH3 | YY1 | RAVER2 |
| ZFYVE27 | TTC12 | HDDC3 | IGFBP5 | HEATR5A | CRLF3 |
| RNASEH2B | CARS2 | STARD4 | SMYD3 | WDHD1 | DDX60 |
| SH3PXD2A | C17orf75 | GCA | RPL10L | NSD2 | HIGD1A |
| TNS2 | CRLF2 | TRIM65 | INTS11 | MDP1 | EXOG |
| ATG16L1 | TNFRSF12A | PBX1 | IMP3 | GLE1 | POLRMT |
| TTI2 | INCENP | UQCC1 | AATF | MTMR6 | MRPS30 |
| ULK3 | INTS9 | NDUFAF1 | MRPS15 | THNSL1 | RRP1 |
| TTC33 | MTRR | EHMT2 | LIG1 | RBFOX2 | CDC16 |
| KDM3B | TRAP1 | HSPD1 | POLA2 | PKMYT1 | KIF21B |
| TTC21B | PTBP2 | UBR5 | CCDC171 | MAP3K7 | NFATC2IP |
| HEATR3 | PALD1 | CDKN2AIPNL | TGS1 | RSL1D1 | TERF2 |
| ZC3HC1 | ISY1 | NAF1 | BAZ1A | FANCI | RIF1 |
| VRK2 | SYNPO2 | PRORP | |||
| (iv) Commonly enriched proteins in (i) and (ii) and (iii) | |||||
|---|---|---|---|---|---|
| KDM3B | |||||
| HMGN5 | |||||
| URB1 | |||||
| PALD1 | |||||
| LSAMP | |||||
| MET | |||||
| DNAJC2 | |||||
| RBM19 | |||||
| AKAP1 | |||||
| INTS9 | |||||
| SNCA | |||||
| MARS2 | |||||
| MAP3K4 | |||||
| INCENP | |||||
| AKAP9 | |||||
| GCA | |||||
| NCAPD3 | |||||
| FAM162A | |||||
| ORC5 | |||||
| ULK3 | |||||
| POLRMT | |||||
| ZC3HC1 | |||||
| PTCD1 | |||||
| NOL10 | |||||
| SHPK | |||||
| XPC | |||||
| SH3PXD2A | |||||
| RAVER2 | |||||
| PTBP3 | |||||
| BOP1 | |||||
| PEG10 | |||||
| TIMM17A | |||||
| SAAL1 | |||||
| CARS2 | |||||
| FANCI | |||||
| HARS2 | |||||
| BAZ1A | |||||
| PLA2G4A | |||||
| APOO | |||||
| WARS2 | |||||
| TRAP1 | |||||
| RSL1D1 | |||||
Four groups are described: (i) proteins whose peptide counts increased more than two-fold in c-MYC-WT/HDFs compared with MYCL-WT/HDFs using SeV on day 3, 5, or 7; (ii) proteins whose peptide counts increased more than two-fold in c-MYC-WT compared with MYCL-WT using EpiP; (iii) proteins whose peptide counts increased more than two-fold in c-MYC-WT compared with c-MYC-ΔMB0 using EpiP; and (iv) commonly identified proteins. n=3 for EpiP reprogramming.